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饮片企业GMP模糊化生存——饮片质量闸门或将近期紧闭
自2008年第一天开始,饮片生产企业跨入GMP时代.然而,令人诧异的是,有七成企业被拒之门外."一个产业中有七成企业不能通过国家的质量管理规范认证,是不正常的,这也体现了这个产业所面临的困境是多么可怕",中国中药协会中药饮片专业委员会秘书长付永德忧心忡忡.
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报复性事实——GMP饮片认证企业生存状况调查
见到付永德秘书长,已是他从毫州回来的第7天.从他一脸焦虑的神情不难看出,调研结果比他出发前掌握的材料更加糟糕,接下来的谈话恰恰印证了记者的猜测.
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Akt对胃腺癌细胞生存与凋亡的影响
我们以胃腺癌细胞AGS为研究对象,采用Akt抑制剂API-2(曲西立滨)干预后分析Akt对胃腺癌细胞生存和凋亡的影响,初步探讨Akt在胃腺癌发生发展中的作用.
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International Society of Physical and Rehabilitation Medicine (ISPRM):strengthening Physical and Rehabilitation Medicine (PRM) worldwide
Physiral and Rehabilitation Medicine (PRM) is the Medicine of Functioning in light of health conditions, under consideration of the person and in interaction with the environment[1-2].PRM focuses on the application of rehabilitation, the third health strategy which complements the preventive and curative health strategies.Thanks to the increasing survival of people after injury and formerly conditions as well as aging populations and an associated increase in chronic conditions, PRM as the leader of the rehabilitation will, over the next decades, assume an ever more important role in the health care systems worldwide.
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体外自动除颤器、救生衣除颤器的使用或两者同时使用?
医院外除颤临床上推荐使用埋藏式心律转复除颤器(Implantable cardiac defibrillator,ICD),关于体外自动除颤器(automated external defibrillators,AED)的使用和讨论也比较多,救生衣除颤器的报道则较少.Winkle[1]在近期综述指出,美国每年有数十万的院外患者死于心脏骤停.众所周知,心脏骤停患者如果未及时得到心脏电复律,生存的机会非常低.电生理学家在给患者置入ICD后,常通过诱发心室颤动并立即除颤来检测ICD功能.这强调了早期除颤是提高生存率的关键.一般来说,除非ICD不能正常工作,置入ICD的患者不需要心肺复苏.
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影响结直肠癌肝转移而行肝切除病人长期生存的预后因素分析
该研究回顾性分析了297例因结直肠癌肝转移而行肝切除的病例,对影响病人远期治疗效果的预后因素进行了探讨.
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KIR B单倍型无关供者造血干细胞移植可提高急性髓细胞白血病患者的无复发存活率
急性髓细胞白血病(AML)患者接受无关供者造血干细胞移植(HSCT)后的存活率与移植相关死亡率和复发率密切相关.由供者杀伤细胞免疫球蛋白样受体(killer- cell immunoglobulin- like receptor,KIR)和受者HLA共同介导的自然杀伤细胞同种异基因反应性可改善受者存活率、促进植入、减少移植物抗宿主病的发生和降低复发率,关系着AML患者的HSCT能否成功.
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微小残留病检测在儿童急性淋巴细胞白血病中的临床价值及应用
近三十年来,联合化疗方案的进展使得儿童急性淋巴细胞白血病(Acute Lymphoblastic Leukemia, ALL)的疗效有了显著提高,5年无病生存率(Event Free Survival, EFS)达到80%以上,但仍不能避免20%~25%的患者终出现复发[1-2].复发已是ALL儿童获得长期生存的主要障碍,是死亡的重要原因,因而它已成为儿童血液肿瘤研究中的一个严峻挑战.研究显示,复发的主要原因之一为化疗完全缓解后体内残存的微量白血病细胞即微小残留病(Minimal Residual Disease, MRD)[3].这些微量白血病细胞从形态学上无法辨认,只能通过免疫学、分子生物学等方法,采用灵敏度高、特异性强的技术进行检测.
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儿童难治性白血病异基因造血干细胞移植的研究进展
儿童白血病单纯化疗疗效理想,急性淋巴细胞性白血病(acute lymphoblastic leukemia,ALL)的5年无病生存率(disease-free survival,DFS)可达80%,急性髓系白血病(acute myeloid leukemia,AML)也可达40%~60%~([1-3]).
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Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether acti-vation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects.
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Several studies have demonstrated that selective serotonin reuptake inhibitor antidepressants can promote neuronal cell proliferation and enhance neuroplasticity both in vitro and in vivo. It is hypothesized that citalopram, a selective serotonin reuptake inhibitor, can promote the neuronal differentiation of adult bone marrow mesenchymal stem cells. Citalopram strongly enhanced neuronal characteristics of the cells derived from bone marrow mesenchymal stem cells. The rate of cell death was decreased in citalopram-treated bone marrow mesenchymal stem cells than in control cells in neurobasal medium. In addition, the cumulative population doubling level of the citalopram-treated cells was signiifcantly increased compared to that of control cells. Also BrdU incorporation was elevated in citalopram-treated cells. These ifndings suggest that citalopram can improve the neuronal-like cell differentiation of bone marrow mesenchymal stem cells by increasing cell proliferation and survival while maintaining their neuronal characteristics.
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手术前后联合区域动脉灌注化疗对中低位直肠癌生存期的影响
直肠癌术后复发和转移制约着根治性切除后患者5年生存率的提高.术前区域动脉灌注化疗可提高进展期直肠癌的根治性切除率[1],术后区域动脉灌注化疗可抑制直肠癌根治性切除后盆腔局部复发和肝转移[2].笔者通过对术前辅助肠系膜下动脉及肝动脉灌注化疗、术后辅助双侧髂内动脉及肝动脉灌注化疗加常规静脉化疗的pT3-4N0-2M0期中低位直肠癌患者临床资料的回顾性分析,探讨手术前后联合区域动脉灌注化疗对直肠癌患者复发和远期生存的影响.
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Objective To explore the efficacy and safty of sorafenib in Child-Pugh class B to class C hepatocellular carcinoma (HCC).
Methods In this three-center open-label study from November 2011 to May 2013, we randomly assigned 189 patients with advanced Child-Pugh class B or C HCC patients into two groups, one group with 95 patient to receive sorafenib (400 mg a time, twice a day) and the other group with 94 patients to receive best supportive care. The primary end points were progression-free survival and overall survival.
Results The median progression-free survival was 2.2 months and 1.9 months in the sorafenib group and best supportive care group respectively (Hazard ratio in the sorafenib group, 0.55; 95% confidence interval, 0.40-0.75;P=0.002). The median overall survival was 4.0 months and 3.5 months in the sorafenib group and best supportive care group respectively (Hazard ratio in the sorafenib group, 0.48;95%confidence interval, 0.35-0.68;P<0.001). The main adverse effect of sorafenib was rash and acne of the skin (in 51.7%patients). The incidences of severe rash, diarrhea, and dry skin were 5.6%, 5.6%, and 2.2%in the sorafenib group. One patient reached partial response in the sorafenib group.
Conclusions Sorafenib is safe in patients with liver function impaired advanced HCC. It is effective in terms of progression-free survival and overall survival compared with best supportive care. Liver functions are the important predictive factors. -
应对严峻的市场:个体医生奋力求生
为了说明他们所处的境遇,缅因州的一些个体诊所的医生经常引用他们的一个同事的辛酸经历.
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1396例子宫平滑肌肉瘤的预后和生存因素
本研究旨在探讨与子宫平滑肌肉瘤(LMS)的病变特别生存(disease-specific survival,DSS)相关的预后因素,分析淋巴结切除在治疗中的作用.
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1396例子宫平滑肌肉瘤的预后和生存因素
本研究旨在探讨与子宫平滑肌肉瘤(LMS)的病变特别生存(disease-specific survival,DSS)相关的预后因素,分析淋巴结切除在治疗中的作用.
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生存体验:一场做秀的心理游戏
2009年2月25日,沈阳14名在校大学生到大连进行了为期两天的生存体验:为企业提供相关的理念和工作方法的培训,目标是创造3000元钱的价值和返程路费,以此来证明大学生自主创业是完全可行的.从这个超现实的目标可想而知结果会怎样,终一家企业的负责人答应给这些年轻人一个机会:支付他们的返沈车费,给予他们一项针对大学生群体的社会调查并预支600元的费用.事实上,如果没有媒体的预先关注和全程介入,恐怕连这600元费用大学生们也不可能拿到.当然,即便没有回程路费,大学生也不必担心终会流落街头,因为两天的"体验"期一过,他们就可以回归正常的生活了.
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长期生存者资料统计分析方法研究进展
生存分析(survival analysis)是将终点事件的发生和发生终点事件的时间结合起来分析的一种统计分析方法.它可充分利用资料中的删失信息,更准确地评价干预所产生的效应[1].生存资料中可能会出现某些个体不发生甚至永远不会发生终点事件或失效的现象.
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中国儿童生存状况:婴幼儿死亡率变化趋势
儿童的生存、保护和发展是当今国际社会应优先考虑的问题之一,而其中基本的是生存问题.长期以来,国际上衡量儿童生存状况的主要指标是婴儿死亡率(infant mortality rate,IMR).
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完全切除的Ⅰ期,Ⅱ期和ⅢA期非小细胞肺癌术后放疗联合辅助化疗对生存率的影响:国际诺维本辅助治疗组织随机临床试验
研究背景:1998年术后放疗(post operative radiotherapy,PORT)的meta分析表明术后放疗相关死亡率风险增加21%,术后放疗的作用一直是探讨的热点.