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地黄合剂对多发性硬化患者外周血及脑脊液中T淋巴细胞亚群的影响
多发性硬化(multiple sclerosis, MS)是中枢神经系统原发性脱髓鞘性疾病,病理特点为脑与脊髓的白质中散在的多发性脱髓鞘和继发性胶质增生所形成的硬化斑块.MS的发病机制目前尚未完全清楚,因此,在治疗上仍无特效疗法.1998年1月~2001年6月我们采用地黄合剂治疗MS,取得较好疗效.本研究将着重探讨地黄合剂对MS患者外周血及脑脊液中T淋巴细胞亚群的影响.
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脑膜癌病21例临床研究
目的:探讨脑膜癌病的临床特点及脑脊液细胞学改变,影像学改变.方法:对2002年1月-2008年1月收治的21例脑膜癌病患者的临床资料进行回顾性分析.结果:首发症状多以头痛、呕吐为主,可伴脑神经和脊神经损害及脑膜刺激征;脑脊液压均力不同程度增高,细胞数、蛋白升高,糖、氯化物下降;细胞学检查发现癌细胞.结论:影像学,脑脊液细胞学检查是诊断脑膜癌病的重要依据.
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中枢神经系统感染患儿脑脊液中IGF-Ⅱ及IGFBP-3水平变化的研究
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Peripheral and central sensitizations are phenomena that occur during migraine. The role of pentin, a migraine preventive drug, on central sensitization remains unclear. In this study, a rat model of migraine was established by electrical stimulation of the trigeminal ganglion, and the an-imals were given intragastric gabapentin. Changes in amino acid content in the cerebrospinal fluid and protein kinase C membrane translocation in the spinal trigeminal nucleus were examined to clarify the mechanisms underlying the efficacy of gabapentin in the treatment of central sensitization during migraine. Electrophysiology, liquid chromatography-mass spectrometry and western blot analysis results revealed that gabapentin reduces neuronal excitability in the spinal nucleus in the trigeminal nerve, decreases excitatory amino acid content and inhibits the activation of protein ki-nase C. This provides evidence that excitatory amino acids and protein kinase C are involved in the formation and maintenance of central sensitization during migraine. Gabapentin inhibits migraine by reducing excitatory amino acid content in the cerebrospinal fluid and inhibiting protein kinase C ac-tivation.
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短暂头痛、神经功能缺损伴脑脊液淋巴细胞增多综合征一例
短暂头痛、神经功能缺损伴脑脊液淋巴细胞增多综合征(syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis,HaNDL),曾被称为偏头痛伴脑脊液淋巴细胞增多、假性偏头痛伴脑脊液淋巴细胞增多~([1]),早由Bartleson于1981年提出.近年来,国外HaNDL综合征病例报道逐渐增多~([2-4]),但国内尚未见报道.
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可调压式分流管治疗脑积水(附30例报告)
近年来,可调压阀门脑脊液分流系统(valveregulated cerebrospinal fluid shunt systems)治疗脑积水在发达国家逐渐得到普及,其优点就是术后可根据患者病情变化无创性的调节分流阀门阈值,避免了再次手术更换阀门.作者从2005年1月至2006年6月共为30例患者施行可调压分流阀门的脑室-腹腔分流手术,并与同期使用固定阈值阀门分流管手术的对照组(76例)相比较,疗效满意,并发症少,本文拟对其应用和疗效进行观察和总结.
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脑缺血再灌注损伤后血脑屏障通透性研究进展
血-脑屏障(blood brain barrier,BBB)为中枢神经系统毛细血管腔与神经组织之间存在的所有结构,是脑与血液及脑脊液之间的一种屏障,与中枢神经的变性、损伤和炎症密切相关[1-3].一般来说,BBB包括三部分:BBB、血-脑脊液屏障(blood cerebrospinal fluid barrier,BLB)和脑脊液-脑屏障(cerebrospinal fluid brain barrier,LBB),其中BBB和BLB屏障解剖结构有类似之处,生理和病理意义重大.BBB的组织结构包括脑毛细血管内皮细胞(brain microvessel endothelial cells,BMECs)及其间的紧密连接(tight junction,TJ)、基膜和周细胞、星型胶质细胞终足形成的胶质膜和细胞外基质(extracelluler matrix,ECM).
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中药脑脊液保护神经元损伤的离体实验研究
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Eosinophilic meningitis caused by infection of Angiostrongylus cantonensis in a traveler
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激光扫描共聚焦显微镜技术应用于脑脊液淋巴细胞的系列研究
脑脊液(CSF)细胞学经过长期发展至今,已广泛用于多种神经系统疾病,特别是中枢神经系统感染、肿瘤、白血病、寄生虫病、血管病以及免疫性疾病等的诊断和鉴别诊断[1,2].近10年来,随着各种检测技术的发展,为脑脊液细胞检测研究提供了新的技术和方法,使脑脊液细胞检测具有更大的发展前景和良好的临床应用价值.
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脑脊液置换治疗九例蛛网膜下腔出血患者的观察与护理
蛛网膜下腔出血为自发性非外伤性脑表面血管破裂出血直接流入蛛网膜下腔所致的疾病[1],可很快发生颅内高压,出现剧烈头痛、头晕、恶心、呕吐,严重者抽搐、意识障碍,病情危急,变化迅速,以往多采用长疗程大剂量止血药,配合降颅压、解痉等对症治疗,疗效不满意.
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1例周围性面瘫并脑脊液耳漏的围术期护理
周围性面瘫系面神经核团或其下的面神经各段损害所致的面神经瘫痪,以面部表情肌的瘫痪为显著特征,病人常出现焦虑、自卑心理,影响生活和工作.针对病人病情进行积极评估、予以心理疏导,实施全面的健康教育,使病人积极参与诊疗护理活动,促进病情康复.我科于2008年8月收治1例外伤致周围性面瘫并脑脊液耳漏病人,成功地进行了面神经全程减压术、鼓室成形术、耳甲腔成形术,术后病人恢复良好,面瘫有所改善,听力较前提高,好转出院.现将护理体会介绍如下.
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多梗死性痴呆患者血浆、脑脊液胰岛素含量与智能水平的相关性研究
Objective To study the change of plasma and cerebrospinal fluid (CSF) insulin levels and the relationship to intellectual level in patients with multi infarct dementia (MID).Methods The concentration of insulin in plasma and CSF was determined by RIAs in 55 patients with MID. 72 patients with cerebral infarction(CI) and 32 normal subjects were used as controls. Mini mental state examination (MMSE) was used to examine the intellectual level of patients, with DSM IV diagnosis standard and Hachinski Ischemia Score as references. Results The patients in MID had significantly higher plasma insulin level than that in normal controls ( P < 0.01 ), but lower CSF insulin and reduced CSF to plasma insulin ratio (P< 0.01). There was a positively correlated between CSF to plasma insulin ratio and MMSE score for MID as a whole. The patients in CI acute phase group had a higher plasma insulin levels than that in normal controls ( P < 0.05 ) , but CSF to plasma insulin ratio differed statistically from either MID acute episode group or stationary phase group ( P < 0.01 ). Conclusion The change of plasma and CSF insulin levels may be one of the pathophysiological mechanisms that bring about intellectual level decline in MID. CSF to plasma insulin ratio may be used as a marker of intellectual level declining for patients with MID.
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医用智能控温仪对蛛网膜下腔出血患者神经功能恢复的疗效观察
1 Subject and method 1.1 Subject 121 SAH patients treated in our department from January 1996 to August 2001 were chosen, 93 male cases and 28 female cases with ages from 35 to 55 and the average age of (43.0± 3.2), they were all taken in hospital in 72 hours after first attack and they were all accorded with the standards set in the 2nd national cerebral vessels academic conference of 1996. the scores were 35~ 45 and they were conformed with CT or MRI, the cerebrospinal fluid showed positive result and there were no other severe compliments, the relatives were willing to take YZK treatment.
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目的:进一步明确小儿Fisher氏综合征的病因及诊断标准。方法: 对22例小儿Fisher氏综合征的临床表现、脑脊液进行对比研究。结果:22例患儿均以眼肌 麻痹和小脑共济失调为主征,伴有肢体不同程度的不完全的弛缓性瘫痪,约半数以上病儿脑 脊液出现蛋白、细胞分离现象。结论:Fisher氏综合征是急性感染性神经根神经炎(AIP)一 种 特殊型或变异型,是以小脑共济失调为主的颅神经受损的AIP。
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病毒性脑炎患儿脑脊液NO及TNF-α的测定及其意义
一氧化氮(nitric oxide,NO)作为体内重要的生理递质及化学信使既参与了生理功能的调节也在病理过程中发挥了复杂的作用.近年来NO在中枢神经系统感染中的作用日益受到重视.
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腰大池持续外引流术在神经外科的临床应用
腰大池持续外引流术(continued lumbar cerebrospinal fluid drainage,CLCFD)可用于神经外科多种疾病的检查、诊断及治疗,其操作简单、安全有效.我院于2003年10月至2009年6月应用CLCFD治疗41例包括蛛网膜下腔出血、脑室出血、持续脑脊液鼻漏、严重而难治的颅内感染和后颅凹开颅术后皮下积液和持续发热病人,获得满意疗效,现总结如下.
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持续腰大池引流在神经外科中的应用与临床价值
持续腰大池引流(lumbar cerebrospinal fluid drainage,LCFD)在神经外科临床中已得到广泛应用[1].LCFD具有创伤小、可控引流速度和引流量、患者恢复快等优点.本科2004年3月至2008年8月应用LCFD治疗脑室内残余血、蛛网膜下腔出血、难治性脑脊液漏、严重颅内感染及顽固性颅内高压患者126例,取得了良好疗效.
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血脑屏障与P-糖蛋白
血脑屏障(blood brain barrier, BBB)指血-脑及血-脑脊液屏障[blood cerebrospinal fluid barrier (BCSFB or BCB)].BBB主要的屏障是脑毛细血管内皮细胞构成的屏障,与其它组织不同的是脑毛细血管内皮细胞紧密联接,缺乏孔道转运和胞饮转运.此外在内皮细胞周围存在大量的胶质细胞,形成了脑微血管的以下特性:(1)低水溶性物质的扩散通透性;(2)低导水性;(3)高反射系数;(4)高电阻性.这些特性的存在限制了一些极性大、电荷性高和大分子化合物进入脑内.
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脑脊液置换治疗蛛网膜下腔出血48例疗效观察
蛛网膜下腔出血(SAH)是一种常见的急性脑血管疾病,因其起病急,病情凶险,致残、致死率高,因此一直成为神经内科重点研究课题。作者自1995年1月至2000年12月探索采用脑脊液置换(permutation of cerebrospinal fluid,PCSF)治疗蛛网膜下腔出血48例,取得了良好的效果。现报告如下。