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关于病理活检在弥漫性泛细支气管炎诊断中地位的个人见解
笔者通过对数十例弥漫性泛细支气管炎(DPB)的诊治实践,认为诊断DPB不应过分强调病理诊断,理由如下.
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大环内酯类抗生素对T细胞巨噬细胞炎性蛋白-1α表达的影响
弥漫性泛细支气管炎(DPB)是以弥漫存在于两肺呼吸性细支气管慢性炎症为特征并可引起严重呼吸障碍的一种疾病.大环内酯类抗生素治疗DPB可获得良好疗效,但治疗机制尚不完全清楚.
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弥漫性泛细支气管炎的研究进展
弥漫性泛细支气管炎(diffuse panbronchiolitis,DPB)是一种以弥漫存在于两肺呼吸性细支气管区域的慢性炎症为特征,引起严重呼吸障碍的疾患.由于炎症病变弥漫性地分布于呼吸性细支气管壁的全层,故称之为弥漫性泛细支气管炎.主要症状为慢性咳嗽、咳痰、活动时气短.现对本病研究进展综述如下:
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大环内酯类抗生素在呼吸系统疾病中的抗炎作用
大环内酯类抗生素的免疫调控作用越来越受到关注.对呼吸系统炎症性疾病的治疗作用受到临床医师的肯定.本文就红霉素及其衍生物罗红霉素、克拉霉素、阿奇霉素等在弥漫性泛细支气管炎(diffuse panbronchiolitis,DPB)、支气管哮喘、囊性纤维化(cystic fibrosis,CF)、支气管扩张、闭塞性细支气管炎(bronchiolitis obliterrans,BO)等呼吸系统疾病中的免疫治疗作用进行了简要总结.
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多层螺旋CT对弥漫性泛细支气管炎的诊断价值
弥漫性泛细支气管炎(diffuse panhronchiolitis,DPB)是以弥漫存在于两肺细支气管和呼吸性细支气管壁全层的的小气道慢性炎症为特征,可引起严重呼吸功能障碍而病因尚未明了的一种疾病.DPB与地域、人种、遗传等多种因素有关,以日本、韩国等东亚国家常见[1],近年来国内报道也日渐增多.DPB临床症状、体征缺乏特异性,误诊、漏诊率高,多层螺旋CT(MSCT)具有分辨力高、多平面成像及无创伤性等优点,是DPB早期检出有效手段,本文着重介绍近年来有关DPB的MSCT表现情况,以提高对其认识和诊断水平.
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改良法制备异种脱蛋白骨复合重组人骨形态发生蛋白支架修复长骨大段骨缺损
BACKGROUND: For its extensive sources and specific biological characteristics, heterogeneous deproteinized bone (DPB) as the tissue-engineered scaffold material gets a good application prospect in repair of large segmental bone defects.OBJECTIVE: To prepare scaffold material by compositing modified heterogeneous DPB with recombinant human bone morphogenetic protein 2 (rhBMP2) and evaluate the osteogenic ability in repairing large segmental long bone defects in large-sized animals.METHODS: Twenty-four goats were randomly and evenly divided into three groups: DPB, autologous bone, and DPB+rhBMP2. Bone defects (20% in length) were made in the middle and lower segments of the right tibia of each goat, and according to group design,different bone grafts were implanted and fixed using semi-ring slot external fixer. At 4-24 weeks after surgery, X-ray examination was performed once every other 4 weeks. At 24 weeks after surgery, newly formed bones were taken out for determining the repair effects of bone defects through duat-energy X-ray analysis, histological observation, and biomechanical analysis.RESULTS AND CONCLUSION: The prepared DPB exhibited a three-dimensional porous structure, with a porosity of (78.5±6.45)% and pore size of (472.5±7.02) μm. Time-dependent bone repair was found in each group. Results regarding anti-compression test, three-point anti-bend test, and anti-torsion test were greatest in the autologous bone group, followed by the DPB+rhBMP2 group, and lastly the DPB group. There were no significant differences in tibial bone density, bone mineral content,anti-compression pressure and ultimate pressure, anti-bending load and ultimate toad, anti-torsion torque and ultimate torque between autologous bone group, DPB+rhBMP2 group and normal bone control group. These findings indicate that modified heterogeneous DPB composited with rhBMP2 has osteogenic ability equivalent to autologous bone in repairing large segmental long bone defects in goat tibias. Therefore, it can be applied as tissue-engineered scaffold material.
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弥漫性泛细支气管炎误诊1例
弥漫性泛细支气管炎(DPB)以弥漫存在于两肺呼吸性细支气管区域的慢性炎症为特征,可导致严重的呼吸功能障碍.如果早期确诊,及时使用红霉素治疗则可以阻止病变进展,使预后大为改观.
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弥漫性泛细支气管炎3例临床分析
弥漫性泛细支气管炎(diffuse panbronchiolitis,DPB)是以肺部呼吸性细支气管为主要病变区域的特发性、弥漫性、炎性和阻塞性气道疾病.本病在1969年由日本学者早报道.在我国也并非罕见,如果早期确诊、及时使用红霉素治疗可以阻止病变进展,改善预后.但由于临床上对该疾病警惕性不高,常易误诊,贻误治疗.本次研究总结3例DPB患者的诊治情况,现报道如下.
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弥漫性泛细支气管炎2例报告
弥漫性泛细支气管炎(Diffuse Panbronchiolitis,DPB)是存在于细支气管和呼吸性细支气管的一种气道慢性炎症性疾病.由于炎症病变呈弥漫性地分布并累及呼吸性细支气管以远的终末气道和呼吸性细支气管壁的全层,故称之为弥漫性泛细支气管炎.
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弥漫性泛细支气管炎12例临床分析
目的 探讨12例弥漫性泛细支气管炎(diffuse panbronchiolitis,DPB)患者的临床特点及诊断方法.方法 参考日本厚生省1998年第二次修订的临床诊断标准,对12例DPB 病例的临床资料进行回顾性分析.结果 12例患者中,病理组织学确诊8例,临床诊断4例.初被误诊为慢性支气管炎的病例(8/12),被误诊为支气管扩张症的病例占(9/12);采用红霉素序贯阿奇霉素治疗后,取得良好效果.结论 DPB误诊率高,大环类酯类抗生素能显著改善患者预后,及时治疗是可以治愈的.
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弥漫性泛细支气管炎3例临床分析
弥漫性泛细支气管炎(DPB)是一种以弥漫存在于两肺呼吸性细支气管区域的慢性炎症为特征的疾病.该病在我国大陆目前报道不超过200例[1],常与慢性支气管炎、粟粒性肺结核、支气管扩张、间质性肺纤维化等疾病有相似之处.
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弥漫性泛细支气管炎继发IgA肾病一例
弥漫性泛细支气管炎(DPB)是以两肺弥漫性呼吸性细支气管及其周围的慢性炎性反应为特征的独立性疾病,临床表现为持续性咳嗽、咳痰及活动时呼吸困难等,并发肾损害少见.我们收治DPB并发IgA肾病1例,并随访1年半,报告如下.
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弥漫性泛细支气管炎与IgA、SIgA关系的研究
目的:探讨弥漫性泛细支气管炎(Diffuse Panbronchiolitis,DPB)与免疫的关系,以及血清免疫球蛋白A(IgA)、分泌型免疫球蛋白A(SIgA)的检测对DPB患者的临床意义.方法:应用放射免疫分析检测36例DPB血清IgA、SIgA,并与50例健康者作比较.结果:DPB患者血清IgA、SIgA含量明显高于健康组(P<0.01),经1个月治疗后差异仍有统计学意义(P<0.05).结论:检测DPB患者血清IgA、SIgA对DPB的诊断及预后有一定的临床意义.