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呼吸道乳头瘤一例
患者男,13岁.因发现双肺结节人院.既往患者于出生后1.5个月因声嘶伴吸气时喉鸣,行喉镜检查发现喉乳头状新生物,活检病理示喉鳞状上皮乳头状瘤;此后病情反复,多次行喉镜新生物摘除手术.患者于2008年8月行CT检查示:左上肺见小结节样高密度影,边界尚清(图1);右上肺见空腔影,薄壁,内未见液平(图2);右中叶内见小结节样、小片状高密度影.
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Objective:To investigate the recurrence sites, risk factors, and prognosis of patients with persistent or recurrent squamous cell carcinoma (SCC) of the cervix within one year atfer undergoing concurrent chemoradiotherapy (CCRT).
Methods:Clinical data of 30 patients with persistent or recurrent SCC of the cervix within one year atfer CCRT between July 2006 and July 2011 were analyzed retrospectively. hTese data were compared with those of 35 SCC cases with no signs of recurrence atfer complete remission. hTese 35 patients were treated during the same period (between 2006 and 2011) and selected randomly.
Results:Among these 30 patients, 25 exhibited distant metastases of which 14 were observed within 6 months atfer CCRT. Univariate analysis showed higher incidence of pelvic or para-aortic lymphadenectasis and SCC-ag>10 ng/mL in the group with persistent or recurrent disease before treatment (P<0.01). Multivariate analysis by logistic regression revealed that the pre-therapeutic pelvic or para-aortic lymph node enlargement and SCC-ag>10 ng/mL were the independent risk factors. Palliative chemotherapy was the main treatment option for patients with persistent or recurrent disease. hTe 2-year survival rate was 21.7%, and the median survival time was 17 months.
Conclusion:Patients with persistent or recurrent SCC of the cervix atfer CCRT exhibited a high rate of distant metastasis with poor prognosis. The pre-therapeutic pelvic or para-aortic lymph node enlargement and SCC-ag>10 ng/mL were identiifed as the independent risk factors for persistent or recurrent SCC within 1 year atfer CCRT. -
高危型人乳头瘤病毒检测在避免ASC-US假阳性诊断中的作用
未明确意义的非典型鳞状上皮细胞(atypical squamous cell of undetermined significance,ASC-US)是TBS报告系统中的一个诊断术语,ASC-US诊断的特异性和重复性均低,目前对ASC-US患者的评价和监测存在广泛争议,由于对诊断标准的理解的不一致导致大量ASC-US假阳性诊断.我们通过对69例ASC-US病例的分析,进一步认识ASC-US的形态学特征并探讨高危型人乳头瘤病毒检测在避免ASC-US假阳性诊断中的意义,为临床诊断提供依据.
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乳腺鳞状细胞癌3例并文献复习
乳腺原发性鳞状细胞癌(primary squamous cell car-cimoma of the breast,SCC)是乳腺癌中一种极为罕见的类型,发病率从0.06%-2%不等[1],占乳腺癌的比例小于1%[2].我院从1990至今又见到三例,本文就其组织学来源、诊断标准和临床治疗作一些探讨.
关键词: 乳腺鳞状细胞癌 乳腺原发性鳞状细胞癌 squamous cell 乳腺癌 诊断标准 临床治疗 组织学 发病率 -
头颈部N0期鳞癌颈部淋巴结的评估及处理
头颈部鳞癌容易发生颈部淋巴结转移,癌瘤通过淋巴道转移到颈部淋巴结后,较长时间停留在颈部.因此,颈清扫术是治疗头颈部鳞癌的主要手段之一.对于临床诊断有颈部淋巴结转移的患者应行根治性颈淋巴结清扫术,对此已有共识,但对临床诊断无颈部淋巴结转移(N0)的处理却仍有不同的见解.这主要是因为,临床颈N0患者中有相当一部分存在亚临床转移,即隐匿性转移(occult metastasis, OM).如何处理颈部可能出现的病灶.
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区别非典型纤维黄色瘤与其他皮肤恶性梭形细胞肿瘤 p40比 p63更具特异性
皮肤低分化恶性梭形细胞肿瘤的诊断非常困难,尤其是低分化梭形细胞鳞状细胞癌( spindle cell squamous cell carci-noma, SpSCC)与非典型纤维黄色瘤( atypical fibroxanthoma, AFX)的鉴别,具有重要的临床意义。早前研究认为 p63能够有效区别 AFX 与 SpSCC,但有文献报道在一些 AFX 中p63亦呈广泛表达,因而限制了在两者鉴别诊断中的应用。近来研究发现 p40免疫组化对鉴别具有鳞状分化的癌较p63更为有效,为此作者选择一组AFX 和SpSCC进行比较分析。
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血管内皮生长因子在口腔鳞状细胞癌中的表达
血管内皮生长因子(vascular endothelial growth factor,VEGF)在肿瘤的发生中起着重要作用.本研究采用免疫组化方法检测了VEGF在口腔鳞状细胞癌(oral squamous cell carci-noma,OSCC)组织中的表达,并且采用RT-PCR方法检测人舌癌细胞系Tca8113中VEGF mRNA的表达,探讨VEGF在口腔鳞癌生长中的作用.
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原发性肾鳞状细胞癌MR诊断1例报告
患者男,26岁,2周前突然出现无痛性血尿,呈淡红色,无血丝、无凝血块,无尿痛,无腰痛,无扣击痛,无发热,无颜面部或肢体肿胀,尿潜血(++++),肿瘤全项TSGF60 ng/ml、AFP 10.560 ng/ml、CEA 5.760 ng/ml、PSA 3.960 ng/ml、铁蛋白220ng/ml(男<100).尿脱落细胞未找到瘤细胞.
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Epidemiology of esophageal squamous cell carcinoma
Esophageal cancer ( EC ) caused about more than 390000 deaths in 2010. EC is the fourth leading cause of cancer death in China. Esophageal squamous cell carcinoma ( ESCC) is the predominant histologic type in China. This study briefly reviews the epidemiology of ESCC, especially focus on the envi-ronmental and genetic risk factors of ESCC.
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人乳头状瘤病毒检测联合阴道镜在宫颈细胞学诊断意义不明的不典型鳞状细胞(ASCUS)妇女诊断中的价值研究
1988年的美国国际癌症协会提出了TBS分类法,从而出现了性质未定的意义不明的不典型鳞状细胞(atypical squamous cell of undetermined significance,ASCUS)的概念.根据宫颈细胞学TBS方法分类在美国每年约有2000万妇女被诊断为AS-CUS,它有特定的诊断标准:细胞异常较反应性改变更明显,但尚未达到鳞状上皮内病变(squamou8 intra-epithelial lesion,SIL)的程度,可以是增生活跃的良性改变或潜在的恶性改变,不能对其进行明确分类而被命名.
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宫颈涂片ASCUS与组织学结果的对比观察
意义不明确的非典型鳞状细胞(Atypical squamous cell of undetermined significance,ASCUS)是宫颈细胞学TBS报告系统中具有挑战性的术语,她凸显出病理医师对细胞学标本常不能做出非黑即白的决定,从而使临床医师对病人是治疗还是不治疗的双向选择处于为难的境地.