首页 > 文献资料
-
神经生长因子和高压氧对新生鼠缺氧缺血性脑损伤后神经再生的影响
新生儿窒息所致缺氧缺血性脑损伤(hypoxic-ischemic brain damage,HIBD),是造成新生儿死亡和导致神经系统后遗症的主要原因,目前临床上以对症支持治疗为主,尚无特效疗法.近年不少文献报道采用神经生长因子(nerve growth factor,NGF)和高压氧(hyperbaric oxygenation,HBO)治疗新生儿HIBD,但疗效不肯定.本研究于2006年4~11月通过建立新生鼠HIBD模型,给予外源性NGF和HBO早期治疗,并结合5-溴脱氧尿嘧啶(BrdU)标记技术,通过动态检测新生鼠脑缺氧缺血后海马齿状回(dentate gyrua,DG)巢蛋白(Nestin)表达、Brdu标记阳性神经细胞数的变化,比较NGF和HBO对新生鼠HIBD后神经增殖再生的影响.
-
早产儿能否进行高压氧治疗?
众所周知,长时间吸入较高浓度氧是导致早产儿视网膜病的重要原因之一.湖南省儿童医院新生儿科就主张早产儿不宜用高压氧进行治疗,非用不可者也要等到(胎龄+出生年龄)满40周后再用.也有专家教授认为,早产儿脑损伤可以使用高压氧治疗,而且越早越好.作为基层医院的医师,我们认为既然高压氧疗法对新生儿脑损伤的疗效不肯定,而且还有副作用,那么,早产儿用高压氧治疗就应严格掌握适应症,慎重应用.但我们确实不知道早产儿能否使用高压氧治疗.
-
Clinical studies have shown that hyperbaric oxygen therapy improves motor function in patients with spinal cord injury. In the present study, we explored the mechanisms associated with the recovery of neurological function after hyperbaric oxygen therapy in a rat model of spinal cord injury. We established an acute spinal cord injury model using a modiifcation of the free-falling object method, and treated the animals with oxygen at 0.2 MPa for 45 minutes, 4 hours after injury. The treatment was administered four times per day, for 3 days. Compared with model rats that did not receive the treatment, rats exposed to hyperbaric oxygen had fewer apoptotic cells in spinal cord tissue, lower expression levels of aquaporin 4/9 mRNA and protein, and more NF-200 positive nerve ifbers. Furthermore, they had smaller spinal cord cavities, rapid recovery of somatosensory and motor evoked potentials, and notably better recovery of hindlimb motor function than model rats. Our ifndings indicate that hyperbaric oxygen therapy reduces apop-tosis, downregulates aquaporin 4/9 mRNA and protein expression in injured spinal cord tissue, improves the local microenvironment for nerve regeneration, and protects and repairs the spinal cord after injury.
-
Hyperbaric oxygen therapy has been widely applied and recognized in the treatment of brain injury;however, the correlation between the protective effect of hyperbaric oxygen therapy and changes of metabolites in the brain remains unclear. To investigate the effect and potential mechanism of hyperbaric oxygen therapy on cognitive functioning in rats, we established traumatic brain injury models using Feeney’s free fal ing method. We treated rat models with hyperbaric oxygen therapy at 0.2 MPa for 60 minutes per day. The Morris water maze test for spatial navigation showed that the average escape latency was significantly prolonged and cognitive function decreased in rats with brain injury. After treatment with hyperbaric oxygen therapy for 1 and 2 weeks, the rats’ spatial learning and memory abilities were improved. Hydrogen proton magnetic resonance spectroscopy analysis showed that the N-acetylaspartate/creatine ratio in the hippocampal CA3 region was sig-nificantly increased at 1 week, and the N-acetylaspartate/choline ratio was significantly increased at 2 weeks after hyperbaric oxygen therapy. Nissl staining and immunohistochemical staining showed that the number of nerve cells and Nissl bodies in the hippocampal CA3 region was significantly increased, and glial fibril ary acidic protein positive cells were decreased after a 2-week hyperbaric oxygen therapy treatment. Our findings indicate that hyperbaric oxygen therapy significantly im-proves cognitive functioning in rats with traumatic brain injury, and the potential mechanism is me-diated by metabolic changes and nerve cellrestoration in the hippocampal CA3 region.
-
高压氧综合治疗脑梗死临床分析
2003~2007年,我科采用高压氧(HBO)对104例脑梗死患者进行综合治疗,并与单纯内科治疗的96例脑梗死患者的疗效进行对比观察,结果 表明高压氧治疗组疗效明显优于单纯内科治疗组.现报告如下.
-
高压氧治疗一氧化碳中毒迟发性脑病的体会
急性一氧化碳(CO)中毒病人经过高压氧治疗后,多数可以痊愈,但10%~30%的病人经过3 d~40 d的"假愈期"可再次出现一系列的神经精神症状,称为CO中毒迟发性脑病.
-
留置插管病人高压氧治疗时的护理
因病情需要,病人经常留置各种插管入高压氧舱进行治疗.如静脉输液管、气管切开气管导管、导尿管、鼻饲管等,这类病人一般病情较严重,稍有不慎极可能发生意外,对病人造成损害甚至危及生命.我科2002年5月-2008年6月共收治留置插管病人133例,在进行高压氧治疗实践中,对留置插管治疗的病人采取了一系列护理措施,效果较好.现报告如下.
-
脑梗死超早期应用高压氧结合感觉输入法康复训练的疗效观察
脑血管意外是当今世界危害人类大的前3种疾病之一.我国是脑卒中发病率较高的国家,而脑梗死占脑卒中的80%,肢体功能障碍是脑血管意外病人神经功能损害普遍、突出的表现,给病人家庭和社会带来了沉重负担.以多种方法结合进行的早期康复治疗是当今脑血管意外治疗的关键,日益受到学术界重视.高压氧作为治疗脑梗死的有效措施,已被公认.
-
高压氧治疗突发性耳聋病人的心理护理
突发性耳聋是一种常见的多发病,起病突然,发病机制复杂,听力在瞬间或几小时、几天内突然下降,重者全聋,常为单侧发病.临床上除常规药物治疗外同时进行高压氧(HBO)治疗.病人因耳聋导致与人交流困难,影响生活和工作,出现心理障碍.因此,在HBO治疗期间,护士对病人进行心理护理十分重要.
-
高压氧治疗突发性耳聋的疗效评价
突发性耳聋是听力在瞬间或很短的时间内突然下降的感音神经性耳聋.高压氧治疗突发性耳聋是一种疗效显著的治疗方法.我院1998年-2005年应用高压氧治疗突发性耳聋38例44耳,取得满意疗效.
-
急性一氧化碳中毒与不同疾患同舱高压氧治疗优先吸氧的效果观察
每年入冬后,基层医院常常遇到急性一氧化碳中毒与常规做高压氧治疗的其他病人在治疗时间上发生冲突的情况,有时因经济方面原因一氧化碳中毒者不愿单独开舱抢救,而常规治疗者多是从乡镇赶车而来,在只有1台中型氧舱的情况下,为了既不耽误抢救又不影响常规治疗,我们常合为一舱处理.
-
急性一氧化碳中毒与高压氧治疗
急性一氧化碳(CO)中毒的发病率和死亡率在我国急性职业危害性疾病中一直居于首位[1,2],且易引起迟发性脑病,严重危害健康并直接威胁生命.美国每年至少有600人死于急性一氧化碳中毒,居中毒性死因之首[3].因此,急性一氧化碳中毒一直是全球性问题.国内外学者已就急性CO中毒的发病机制及临床治疗进行了大量深入研究,并取得一些进展.高压氧(hyperbaric oxygen,HBO)即是成果之一,目前已成为治疗急性CO中毒常用的方法.但近年,不少研究对其治疗基础和临床疗效提出了质疑,值得注意.现就此作一简要综述,为今后工作提供参考.
-
高压氧辅助治疗青年人心肌缺血398例
Background: Main causes of youth myocardial ischemia are smoking and hypercholesterolemia, which leads to disorder of collateral circulation, increase of cardiac accidence and coronary atherosclerosis. Hypoxia is easy to happen because thick of sclerotic vessels wall nearly reaches the maximal diffuse distance in this tissue. CO in cigarettes can lead to hypoxia and myocardial ischemia. After use of hyperbaric oxygen, blood fat decrease, incidence of coronary atherosclerosis decreases apparently. And it promotes myocardial hypoxia and metabolism, increases myocardial contraction and promotes heart function, thereby decrease incidence of angina, myocardial infarction and sudden death.
-
高压氧综合治疗冠心病患者的心电图反应
BACKGROUND:Electrocardiogram(ECG) reaction of patients with coronary heart disease(CHD) are not improved markedly by medical therapy,but the patients' S T,T of ECG are improved obviously by HBO therapy.
-
高压氧对动物有机磷中毒后神经损害恢复的实验研究
Objective To investigate the effect of hyperbarci oxygen(HBO) on recovery of nerves injury in rats suffered from acute organophosphorus poisoning. Method We established organophosphorus poisoning models and observed effect of HBO on recovery of injure nerves. Results Compared with control group, cerebrospinal fluid induced peak potential and incubation period in HBO group were significantly recovered(P<0.05).HBO could accelerated repair of injured nerves. Conclusion HBO could relieve injury of nerves during treatment of organophosphorus poisoning. ``
-
高压氧综合治疗鼻咽癌患者放射性脑损伤26例
INTRODUCTION Because nasopharynx is near to base of skull,radiation therapy might cause radiating brain injury that will influence patient's life quality.
-
高压氧治疗脑梗死疗效观察
Background:Hypoxia and ischemia resulting from cerebral infarction can further cause a series of pathological changes such as hydrocephallus.Drug therapy can improve cerebral blood circulation and enhance flow volume and decrease infarction area.If hyperbaric oxygen is added,pathophysiological changes such as ischemia and hypoxia can be improved and normal metabolism of brain cells be restored.
-
高血压脑出血术后高压氧治疗34例
INTRODUCTION In this study,we investigated effect of hyperbaric oxygen(HBO) on the hypertension- induced basio- cerebral hemorrhage.The affected patients often showed signs of cerebral circulation disorder,spasm of vessels,insufficiency of cerebral blood supply and intracranial hypertension.
-
高压氧治疗颅脑损伤病种、病程、病情、年龄与疗效的相关性分析
Objective To observe the effects when treating craniocerebral injuries with hyperbaric oxygen. Method 61 cases of craniocerebral injuries were treated with HBO. Result Cured: 34 cases (55.7% ), excellent effects: 17cases (27.8% ), effective 7cases (11.5% ), non-effective 3cases (4.9% ), the effective rate was 95.1% . Conclusion HBO is effective on craniocerebral injuries and it is the main aiding treating method of craniocerebral injury rehabilitation treatment.
-
高压氧治疗减轻肢体撕脱伤肿胀、疼痛效果的临床分析
Background: In recent years, most major avulsion of limb skin were caused by traffic accidents, industry accidents and mechanical traumas, the tissue damage, the operational elimination of subcutaneous fat or skin flap transfer may cause ischemia and hypoxia at the wound, the limb swelling and pain were obvious, the routine treatment was slow and of long recovering time. Objective: To discuss the effects of hyperbaric oxygen to reduce the swelling and pain caused by limb avulsion. Unit: The People's Hospital of Sanshui.