首页 > 文献资料
-
慢性肾衰竭患者血浆脑钠肽水平与心功能的关系研究进展
钠尿肽类激素主要分3种:①心房钠(ANP):由心房细胞分泌,应激反应为心房膨胀;②脑钠肽或称B型钠尿肽(BNP):由心室肌细胞分泌,应激反应为心室膨胀;③血管钠尿肽(CNP):由内皮细胞分泌,应激反应为内皮细胞坏死.
-
超声新技术在心脏功能评估中的应用
心脏功能的评估对于患者病情的判断、治疗方案的选择、疗效及预后的评价均有极为重要意义.超声以方法简便、无创、准确等优越性被广泛应用于临床,评价心功能已成为超声心动图检查的一个重要部分.
-
Objective To investigate the G protein-coupled receptor kinase 2 (GRK 2) level in peripheral blood lymphocytes with cardiac func-tion in elderly patients with acute myocardial infarction. Methods This study enrolled 40 patients with acute ST-segment elevation myo-cardial infarction (STEMI) and 40 patients with unstable angina. All patients were 65 years or older. Cardiac function was evaluated by echocardiography, and the GRK 2 level in peripheral blood lymphocytes was measured. Patients with STEMI were followed up for 2 years. Results The GRK 2 level in peripheral blood lymphocytes was significantly higher in patients with STEMI than in patients with unstable angina, and was negatively correlated with left ventricular ejection fraction, cardiac output, stroke volume, and left ventricular fractional shortening. The GRK 2 level was significantly elevated in some patients with acute STEMI and poor cardiac function. Conclusions In-creased GRK 2 level in patients with acute STEMI may contribute to poor myocardial systolic function and myocardial remodeling. Meas-urement of the GRK 2 level in peripheral blood lymphocytes may assist in the evaluation of cardiac function and myocardial remodeling in elderly patients with acute STEMI.
-
骨髓间充质干细胞移植改善心功能机制的研究进展
当前心血管疾病已成为世界威胁人类健康的重大疾病,利用各种干细胞实现心肌和血管的再生已成为世界心血管病学研究的热点之一.在过去的5年里,间充质干细胞(bone mesenchymal stem cells,BMSCs)在心脏病的治疗得到了越来越多的关注.无论是基础实验研究还是临床试验研究,都取得了显著的成果.2004年3月美国得克萨斯心脏研究所获得美国FDA批准干细胞用于难治性心力衰竭的临床研究,标志着干细胞用于临床已逐渐进入科学化和法规化的轨道.本文就近几年有关BMSCs心脏移植术后能够改善心功能的机制的研究作一综述.
-
双胎输血综合征胎儿心功能改变的超声研究进展
双胎输血综合征(twin to twin transfusion syndrome,TTTS)是发生在单绒毛膜囊双胎的一种严重畸形,双胎分别呈现为"供血儿"和"受血儿"的特征表现,如果不采取治疗措施,胎儿宫内死亡的发生率极高.
-
高压氧辅助治疗青年人心肌缺血398例
Background: Main causes of youth myocardial ischemia are smoking and hypercholesterolemia, which leads to disorder of collateral circulation, increase of cardiac accidence and coronary atherosclerosis. Hypoxia is easy to happen because thick of sclerotic vessels wall nearly reaches the maximal diffuse distance in this tissue. CO in cigarettes can lead to hypoxia and myocardial ischemia. After use of hyperbaric oxygen, blood fat decrease, incidence of coronary atherosclerosis decreases apparently. And it promotes myocardial hypoxia and metabolism, increases myocardial contraction and promotes heart function, thereby decrease incidence of angina, myocardial infarction and sudden death.
-
雌孕激素替代治疗对大鼠心血管功能的保护作用
Objective To observe the change of the cardiovascular effect of estrogen replacement therapy in rat after treated with progesterone. Method Thirty female rates were randomly divided into three groups: group A: ovarietcomy; group B: ovariectomy with estrogen replacement therapy and group C: ovariectomy with estrogen and progesterone replacement therapy. The estrogen receptors (ER) in the artery of the rat were measured and the serum level of nitric oxide (NO), endothelin 1 (ET 1), prostacyclin (PGF1a) and thromboxane (TXB2) were detected 2 months later. Results (1) There was no apparent difference in ER expression, serum NO and PGF1a level between group C and group B; these index of group B and C were higher than those of group A; (2) there was no significant difference in blood viscosity, the congregate index of red blood cell and platelet adhesiveness rate between group B and C; these index of group B and C were lower than those of group A. Conclusion Estrogen replacement therapy adding progesterone makes no influence on arterial ER expression, hemorheology index and regulation of estrogen to cardiovascular cytokines generation. It suggested that estrogen combined with progesterone replacement therapy could be a safe and effective method to prevent coronary heart disease.
-
一例股骨头置换合并肺心病及心功能失代偿期患者的护理
人工股骨头置换是治疗高龄股骨颈头下型骨折患者的首选,其优点是能够早期下床行走,避免长时间卧床,减少出现各种并发症.我科于2006年3月收治1例左股骨颈头下型骨折合并肺源性心脏病且心功能失代偿的病人.由于该患者年龄大,合并严重心肺疾病.增加了手术危险.经过周密术前准备,术后精心治疗及护理.疗效满意.现报告如下.
-
Exosomes secreted by mesenchymal stem cells have shown great therapeutic potential in regenerative medicine .In this study, we performed meta-analysis to assess the clinical effectiveness of using exosomes in ischemia /reperfusion injury based on the reports pub-lished between January 2000 and September 2015 and indexed in the PubMed and Web of Science databases .The effect of exosomes on heart function was evaluated according to the following parameters:the area at risk as a percentage of the left ventricle , infarct size as a percentage of the area at risk , infarct size as a percentage of the left ventricle , left ventricular ejection fraction , left ventricular frac-tion shortening , end-diastolic volume , and end-systolic volume .Our analysis indicated that the currently available evidence confirmed the therapeutic potential of mesenchymal stem cell-secreted exosomes in the improvement of heart function .However , further mechanis-tic studies, therapeutic safety and clinical trials are required for optimization and validation of this approach to cardiac regeneration after ischemia/reperfusion injury .
-
高血压病患者淋巴细胞β2受体密度变化与左室肥厚及心功能的关系
本文应用[3H]-DHA放射性配基结合技术测定了不同心功能高血压病患者外周血淋巴细胞β2受体密度的变化.
-
钙拮抗剂对老年高血压病患者左室肥厚及心功能的影响(附30例分析)
-
Doppler超声心动图技术评价肺栓塞患者右心功能的价值
肺栓塞是一种常见的心血管疾病,无论是急性肺栓塞或栓塞性肺动脉高压均可能影响右心功能,因此评价肺栓塞患者的右心功能对该疾病的诊断、治疗及评价预后均有重要的临床意义.早在1992年Torbicki等[1]就探讨了关于多普勒超声心动图在肺栓塞诊断中的意义及其优势.本文就Doppler超声心动图技术对肺栓塞患者右心功能的评价作一简要的综述.