首页 > 文献资料
-
绝经期激素替代疗法
SUMMARY Hormone replacement therapy (HRT) was initiated almost half a century ago to treat menopausal symptoms. Initially, its use remained limited even among symptomatic women and the move toward postmenopausal hormone use for disease prevention came later. Improved treatment schedules and delivery systems expanded the use of HRT worldwide. However, large trials of postmenopausal hormones with disease outcomes were even later in coming and today HRT has become a specialized, multidisciplinary area of research. As the population continues to grow older, there has been an increased focus on the effects of ageing. HRT may affect length and quality of life through disease prevention. It may have possible beneficial effects on cognition, on the incidence of hip fracture, myocardial infarction and stroke, and adverse effects on the incidence of breast cancer, endometrial cancer, and venous thromboembolism.Today's attitudes about the hormonal treatments for the menopausal transition have moved from expansive optimism to contracting disappointment amidst safety concerns and equivocal results and faces greater skepticism and scrutiny. The health and well being of large numbers of women are at stake, and researchers, clinicians and the general public are watching and weighing the options.
-
雌孕激素替代治疗对大鼠心血管功能的保护作用
Objective To observe the change of the cardiovascular effect of estrogen replacement therapy in rat after treated with progesterone. Method Thirty female rates were randomly divided into three groups: group A: ovarietcomy; group B: ovariectomy with estrogen replacement therapy and group C: ovariectomy with estrogen and progesterone replacement therapy. The estrogen receptors (ER) in the artery of the rat were measured and the serum level of nitric oxide (NO), endothelin 1 (ET 1), prostacyclin (PGF1a) and thromboxane (TXB2) were detected 2 months later. Results (1) There was no apparent difference in ER expression, serum NO and PGF1a level between group C and group B; these index of group B and C were higher than those of group A; (2) there was no significant difference in blood viscosity, the congregate index of red blood cell and platelet adhesiveness rate between group B and C; these index of group B and C were lower than those of group A. Conclusion Estrogen replacement therapy adding progesterone makes no influence on arterial ER expression, hemorheology index and regulation of estrogen to cardiovascular cytokines generation. It suggested that estrogen combined with progesterone replacement therapy could be a safe and effective method to prevent coronary heart disease.
