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血管紧张素转换酶在庆大霉素诱导的大鼠急性肾衰竭中的变化
血管紧张素转换酶(ACE)是肾素-血管紧张素系统 (RAS)的关键酶之一,其主要生理功能是将血管紧张素I(AngI )转化为效应肽AngⅡ[1].肾脏自身存在RAS,AngⅡ具有丝裂原活性,可以促进细胞增殖.急性肾衰竭的恢复伴随着小管细胞的增殖,ACE作为AngⅡ转化酶,其在ARF中的变化及意义报道较少,本研究于2004年5月至12月通过对庆大霉素(GM)诱导的大鼠急性肾衰竭(ARF)肾皮质、血浆、尿液中ACE活性的研究,探讨ACE在ARF中的变化.
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Objective: To understand the relationship between Cu,Zn SOD and amyotrophic lateral sclerosis. Methods: The patients were clinically examined and classified according to the E1 Escorial Criteria, then we obtained blood samples from the patients for Cu,Zn SOD analysis and SOD assay. Amino acid analysis of Cu,Zn SOD were fully automated in instruments called amino acid analyzers. SOD assay was determined by cytochrome c method Results: Amino acid analysis of Cu,Zn SOD from patients with familial ALS was normal. The activity of Cu,Zn SOD was normal both in familial and sporadic form of ALS compared with normal person. Conclusion: Amyotrophic lateral sclerosis is not related to Cu,Zn SOD.
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双下肢骨折大鼠血液粘度及血清酶活性变化
骨折在临床多见,由骨折所引起的一系列神经体液反应,导致患者机体出现多种应激性损伤以及血流动力学改变,从而引起器官功能的变化.因此,很多学者应用骨折的方法复制多器官功能障碍综合征(MODS)模型[1].为了进一步探讨多部位骨折对患者器官功能障碍的影响,本研究复制大鼠双后肢骨折模型,观察大鼠骨折后血液流变学及血清酶学的变化,为临床预防骨折诱发MODS提供实验依据.