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硬膜外药物滴注并手法还纳治疗腰椎间盘突出症87例
INTRODUCTIONThere are a lot of non-operative managements for prolasped lumbar intervctebral disc. Epidural injection of drugs, manual reduction were used for prolapsed lumbar intervetebral disc (PLID) combining advantages of various non-operative managements and types of PL[D, age and course of disease. We observed the therapeutic effect.
关键词: 硬膜外 药物滴注 手法 治疗 therapeutic effect -
脑卒中后吞咽困难的中医疗法治疗
INTRODUCTIONDysphagia is common after stroke[1], which correlates closely withdisability and mortality. From May 2001 to November 2002, 38 pa-tionts with dsyphagia following stroke were treated with Chinesetraditional therapy including aucpuncture, ice therapy, and Chinesedrugs induction by ions, and favorable therapeutic effect was ob-served. Here is the report.
关键词: 脑卒中后 吞咽困难 中医疗法 治疗 therapeutic effect -
施行糖尿病患者康复教育的临床意义
Background:Diabetes is a kind of chronically permanent disease.Management during hospitalization was insufficient.Now,health education is the important project in diabetes study.Patients' lifestyle ,attitude to condition and previous treatment showed obvious impact on diabetes control.Some investigators indicated patients had less knowledge about diabetes-related matters,and their self-health idea was unobvious.They rarely abided by physicians' demands.So,rehabilitative education is important for diabetes patients. Objective:To observe the therapeutic effect of rehabilitative education on diabetes patients. Unit:Department of Leader Health,Laiwu People's Hospital. Subjects:80 diabetes were recruited during July 1997 to July 2001.Among these patients,46 were males,34 were females aged 12~ 72(mean age:56.5).42 had high school education and others had middle school education. Intervention:Based on education project for diabetes developed by Endocrine Institute of Hunan Medical University,health education was conducted during hospitalization.After admission,《 Elementary knowledge about diabetes prevention and treatment》 was given to patients.Extensive education ways were used for diabetes patients and their family members.Patients can seek tele-medical directions with telephone or letters according to their demands. Patients were evaluated before and after education. Main prognosis indexes:Comprehensive condition for elementary knowledge about diabetes,fasting blood glucose and accordance behavior were evaluated. Result: (1)Elementary knowledge about diabetes was mastered by 26% patients before education and 80% after education.(2)Fasting blood glucose was (8.22± 0.80)mmol/L before education and (6.10± 0.50)mmol/L after education(P< 0.05).Follow-up showed no changes in fasting blood glucose after discharge.(3) Accordance rate of drugs uptake,diet control,activity intensity,detection of blood glucose and urinary glucose was 50% before education and 85% after education. Conclusion:Rehabilitative education can enhance patients' self regulation and self detection ability,delay development of complications.
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以易化技术为主的康复治疗对脑卒中患者ADL能力的影响
To improve ADL,quality of life,and realize goal of returning society,we performed rehabilitation therapy centralized on facilitation on 40 stroke patients and obtained good therapeutic effect.Here is the report. 1 Subject and method 1.1 Subject 80 inpatients with stroke recruited during 1997~ 2000 were randomly divided into rehabilitation group and control group,each group having 40 cases.Patients in rehabilitation group were 45~ 74 years of age(mean age:56 years) including 32 men and 8 women.13 cases in rehabilitation group suffered from cerebral hemorrhage,27 from cerebral infarction,22 from left paralysis,and 18 from right paralysis.Patients in control group were 43~ 75 years of age(mean age:55 years) including 29 men and 11 women.24 cases in rehabilitation group suffered from cerebral hemorrhage,18 from cerebral infarction,24 from left paralysis,and 18 from right paralysis.All diagnoses were carried out according with 4th national cerebrovascular disease meeting of China in 1995[1] and confirmed by CT or MRI.
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女性偏头脑相关因素及西比灵的防治研究
Objective To observe the relationship of sibelium between vasodilatlting and vasoconstricting factors, and the treating and preoeating effect of sibelium on migraine in women Methods 60 women wre randomly divided into the xueshuantong group( n= 30) and sibelium group(n = 30). We compared the therapeutic effect in the two groups, detected endothelins(ET) and calcitonin gene - related peptide (CGRP) in blood before and after treatment Results In sibelium group, the concentration of CGRP after treatment was lower than that before treatment.Sibelium lightened the extent of heodoche, reduced the duration of headache( both effciency rate of 93% ). Xueshuantong could only lighten the degree of headache(effuctive rate: 70% ). Conclusion Sibelium could control the attack of migraine in women without obvious side effect.
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雪莲黄酮对大鼠创伤性脑水肿的治疗机制研究
Background: A large amount of free radical formation and lipid peroxidization play an important role in development of traumatic cerebrodema.xuelianhuangtong showed a strong effect antiinflammatory and antiperoxidization ,and might have an therapeutic effect on treatment of cerebrodema.No report about this was published.
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BACKGROUND: Studies have shown that sodium hyaluronate inhibits cartilage damage in osteoarthritis and accelerates regeneration of cartilage cels, to stabilize and repair the articular cartilage.
OBJECTIVE:To investigate the therapeutic effect of sodium-rich plasma combined with platelet-rich plasma (PRP) on rabbit knee osteoarthritis.
METHODS:Forty New Zealand white rabbits were randomly divided into five groups, control group, combined group, sodium hyaluronate group, PRP group and model group, and then an osteoarthritis model of the right knee was made in each rabbit. After modeling, sodium hyaluronate+PRP, sodium hyaluronate, autologous PRP and normal saline were givenviathe knee joint cavity in the latter four groups, respectively, once a week for 5 weeks. The control group received no treatment, as normal controls. At 1 week after treatment, ELISA assay was used to detect serum interleukin-1, interleukin-6, tumor necrosis factor-α levels, and changes of the articular cartilage were observed under a light microscope.
RESULTS AND CONCLUSION:Compared with the control group, the levels of interleukin-1, interleukin-6 and tumor necrosis factor-α were al increased in the other four groups (P < 0.01). Compared with the model group, the levels of interleukin-1, interleukin-6 and tumor necrosis factor-α were lowered significantly in the combined, sodium hyaluronate and PRP groups (P< 0.01 orP< 0.05), and the most significant decline was in the combined group. Articular cartilage damage was severest in the model group and mildest in the combined group. Experimental findings indicate that intra-articular injection of sodium hyaluronate+PRP can reduce inflammation and protect the articular cartilage in knee osteoarthritis, which is better than a single drug injection. -
降纤酶治疗糖尿病周围神经病变的临床思路刍议
目的:观察丹红注射液联合降纤酶对糖尿病周围神经病变患者的治疗效果。方法:96例糖尿病周围神经病变患者被随机分为治疗组(丹红注射液联合降纤酶)和对照组(常规治疗),两组患者经治疗后进行疗效评定。结果:治疗组总有效率85.4%,对照组为68.8%,两组比较,差异有统计学意义(P<0.01)。结论:丹红注射液联合降纤酶治疗糖尿病周围神经病变近期疗效较好。
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东海县农民糖耐量低减综合干预治疗5年效果评价
糖耐量低减(IGT)是重要的演变(无统一名称,也称为转化、恶化、发展、转归等)为糖尿病和造成大血管病变的危险人群[1].IGT的形成和演变受多种因素影响,为减少和阻断其演变并促使IGT转为正常,我们对1996年在东海县农民糖尿病流行病学调查中查出的IGT进行了5年的综合性干预治疗管理[2-3],观察其演变结果和血糖、血脂、血压等影响因素的变化,并与对照组作了比较,报告如下:
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甘草酸软膏治疗豚鼠慢性湿疹模型的实验研究
目的 观察甘草酸软膏抗炎、止痒和对豚鼠慢性湿疹的治疗作用.方法 雄性昆明种小鼠、雌雄昆明种小鼠、白色豚鼠各60只,分别随机分为模型对照组(10只)、基质对照组(10只)、醋酸地塞米松乳膏组(10只)、甘草酸软膏高(10只)、中(10只)、低(10只)剂量组,各组分别建立二甲苯致小鼠耳廓肿胀模型,右旋糖酐40致小鼠搔抓模型,以及2,4-硝基氯苯反复刺激的慢性湿疹豚鼠模型,分别观察甘草酸软膏对小鼠耳廓肿胀和搔抓反应以及慢性湿疹豚鼠耳廓肿胀的影响.结果 甘草酸软膏高、中剂量可以抑制二甲苯致小鼠耳廓肿胀(P< 0.05或0.01);甘草酸软膏高剂量可以延长有旋糖酐致小鼠搔抓的潜伏期,甘草酸软膏高、中、低剂量可减少搔抓次数(P< 0.05或0.01),减轻慢性湿疹豚鼠模型耳廓的肿胀(P<0.05或0.01),并对耳廓皮肤的病理改变有一定的改善作用.结论 甘草酸软膏对慢性湿疹豚鼠模型有一定的治疗作用.
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地塞米松对系统性红斑狼疮阴虚内热证患者外周血单一核细胞基因表达谱的影响
目的 探讨地塞米松对系统性红斑狼疮(SLE)阴虚内热证患者外周血单一核细胞(PBMC)基因表达谱的影响.方法 用地塞米松孵化SLE阴虚内热证患者PBMC,收集孵化后细胞进行PBMC的基因表达谱检测.结果 地塞米松上调85个PBMC基因,下调126个PBMC基因.结论 地塞米松调控SLE阴虚内热证患者PBMC的基因所属功能簇众多,基因编码的功能蛋白分布细胞多个部位,不是所有基因调控结果均有利于SLE缓解,一些基因调控作用对研究地塞米松治疗SLE的机制有帮助.
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醋酸棉酚阴道局部给药治疗大鼠子宫内膜异位症的疗效研究
疼痛是深部浸润型子宫内膜异位症(deep infiltrating endometriosis, DIE)的主要临床症状.虽然DIE病灶手术切除能减轻或消除患者的疼痛症状,但该病的病灶及疼痛症状又会重新复发,后导致卵巢的去势手术.
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AIM:Vascular smooth muscle cell (SMC) proliferation and migration from the arterial wall media into the intima are believed to play a critical role in the pathogenesis of restenosis. Several studies have demonstrated that phosphothioate (PS) oligodeoxynucleotides targeted against genes involved in SMC proliferation inhibits in vitro SMC proliferation and migration. However, the therapeutic effect of antisense ODN on the individual who receives the treatment of delivery of the agent depends on the efficacy of this agent in great degree. We investigated the inhibition effect of a novel agent, insulin-antisense-c-myb-PS-ODN on SMC proliferation in vitro. METHODS:The rat aortic artery SMCs were cultured in Dulbecco's modified Eagel's medium. The passage 8 to 13 were used as the experiment. Cell surface receptor binding assay was quantified through counting gamma particles emitted from 125 I labeled insulin. SMC rapid proliferation was brought by stimulation of high concentration of fetal bovine serum (FBS). The novel agent of insulin conjugated to the antisense-c-myb-PS-ODN was obtained via incubation of both in condition of certain reagents, pH, temperature, and ion concentration. The characterization and purification of the agent was performed through HPLC. Inhibition of SMC proliferation was reflected by incorporation rate of trillium labeled thymidine deoxyribonucleotide.RESULTS:The binding efficacy of insulin to the receptor was remarkably increased in SMC cultured in supplement of 20% FBS. The inhibition effect of conjugator insulin-c-myb-antisense-PS-ODN was stronger than that of the simple c-myb-antisense-PS-ODN. The inhibition rate of conjugator and simple form on SMC proliferation were 48.34% and 29.54%, respectively. CONCLUSION:The binding efficacy and specificity of c-myb-antisense-PS-ODN to SMC may be enhanced by the insulin receptor mediation through the insulin-insulin receptor interaction. The insulin-receptor targeted method may be a potential and specific therapeutic pathway for restenosis.
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益气涤痰化瘀汤治疗老年肥胖者冠心病心绞痛128例疗效分析
我们1992~1997年采用自拟益气涤痰化瘀汤治疗老年肥胖者冠心病心绞痛,并与临床常用的加味血府逐瘀汤对照,共观察198例,现报道如下.
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MRI在糖尿病足的影像诊断及自体干细胞移植治疗效果监测的研究进展
随着我国人民生活水平的不断提高,糖尿病的发病率在快速增长,由此所致的糖尿病足的发生率也越来越高,糖尿病足的预后较差,终的结局常常是溃疡、截肢和死亡[1],因此对其进行及时、准确诊断及选择合适、有效的治疗方法决定其预后,得到国内外学者的广泛重视,成为许多学者的研究课题[2].目前,自体骨髓干细胞移植治疗糖尿病足是一种新的治疗方法,对其疗效的评估尚缺乏准确简便易行的客观依据.本文结合国内外资料,分析总结MRI在糖尿病足的诊断价值,为糖尿病足的诊断开辟一种准确客观的影像学诊断依据,并分析采用MRI监测自体干细胞移植治疗糖尿病足治疗效果的可行性.