首页 > 文献资料
-
愈痫灵对致痫大鼠颞叶及海马病理学损害的预保护作用
近中颞叶硬化(mesial temporal sclerosis,MTS)主要指海马硬化(hippocumpal sclerosis,HS),是癫痫的一个重要病理改变.愈痫灵是临床验证的有效经验方[1],为探讨其对癫痫大鼠脑组织损害的保护性作用,以KA诱发大鼠急性GTCS,通过光镜观察药物预处理后对癫痫颞叶和海马的组织学变化,现报告如下.
-
Voxel-based morphometry can be used to quantitatively compare structural differences and func-tional changes of gray matter in subjects. In the present study, we compared gray matter images of 32 patients with Parkinson’s disease and 25 healthy controls using voxel-based morphometry based on 3.0 T high-field magnetic resonance T1-weighted imaging and clinical neurological scale scores. Results showed that the scores in Mini-Mental State Examination and Montreal Cognitive Assessment were lower in patients compared with controls. In particular, the scores of visuospatial/executive function items in Montreal Cognitive Assessment were significantly reduced, but mean scores of non-motor symptoms significantly increased, in patients with Parkinson’s dis-ease. In addition, gray matter volume was significantly diminished in Parkinson’s disease patients compared with normal controls, including bilateral temporal lobe, bilateral occipital lobe, bilateral parietal lobe, bilateral frontal lobe, bilateral insular lobe, bilateral parahippocampal gyrus, bilateral amygdale, right uncus, and right posterior lobe of the cerebel um. These findings indicate that voxel-based morphometry can accurately and quantitatively assess the loss of gray matter volume in patients with Parkinson's disease, and provide essential neuroimaging evidence for multisystem pathological mechanisms involved in Parkinson’s disease.
-
Brain structure and cognitive function change in the temporal lobe, hippocampus, and prefrontal cortex of patients with mild cognitive impairment and Alzheimer’s disease, and brain network-connection strength, network efficiency, and nodal attributes are abnormal. However, existing research has only analyzed the differences between these patients and normal controls. In this study, we constructed brain networks using resting-state functional MRI data that was extracted from four populations mal controls, patients with early mild cognitive impairment, patients with late mild cognitive impairment, and patients with Alzheimer’s disease) using the Alzheimer’s Disease Neuroimaging Initiative data set. The aim was to analyze the characteristics of resting-state functional neural networks, and to observe mild cognitive impairment at different stages before the transformation to Alzheimer’s disease. Results showed that as cognitive deficits increased across the four groups, the shortest path in the rest-ing-state functional network gradual y increased, while clustering coefficients gradual y decreased. This evidence indicates that dementia is associated with a decline of brain network efficiency. In tion, the changes in functional networks revealed the progressive deterioration of network function across brain regions from healthy elderly adults to those with mild cognitive impairment and Alzhei-mer’s disease. The alterations of node attributes in brain regions may reflect the cognitive functions in brain regions, and we speculate that early impairments in memory, hearing, and language function can eventual y lead to diffuse brain injury and other cognitive impairments.
-
第三章创伤性脑实质损伤的外科治疗(二)
4.6 颅内压增高的外科治疗4.6.1 基本原理不同的手术方法已经发展并且运用于治疗创伤性ICP增高后遗症的颅脑减压术中.这些(方法)包括Cushing颞肌下减压术,颞叶切除术,颞叶手工复位术(manualreduction of the temporal lobe)、环状面开颅术(curcumferentialcranioctomy),以及更为广泛使用的半颅骨瓣减压术(hemispheric decompressive craniectomy)和双额去骨瓣减压术(bifrontal decompressive craniectomy).该手术方法的基本原理从人类和动物研究的生理学角度得到支持.减压术后ICP变化和CT扫描特征的研究得到特别关注,诸如脑池消失和中线移位,其目的在于这些术后参数降低明显地与疗效的改善相关联.
-
难治性颞叶内侧痫痈手术的术中配合及护理
癫痫是常见的神经系统疾病之一.它是一种致残率高、临床反复发作、病程漫长的疾病[1].其中,颞叶癫痫分为颞叶内侧癫痫、病灶性颞叶癫痫和颞叶外侧新皮质癫痫.颞叶内侧癫痫主要起源于内侧结构杏仁核、海马、钩回、海马旁回,占颞叶癫痫90%以上的病例.普遍的临床实践已经证明,难治性颞叶内侧癫痫具有良好的手术适应证,术后效果较好.
-
中青年脑血管病后阗痫178例临床研究
1 Subject and method 1.1 Clinical data 178 middle aged patients suffered from epilepsy following cerebrovascular diseases were recriuited including 104 males,74 females aged from 20~ 59 years(mean age:48 years old).Among them,24 cases aged from 20~ 29 years,40 aged from 30~ 39 years,54 aged from 40~ 49 years,60 aged from 50~ 59 years. CT and MRI findings showed ischemic damage in 96 cases, hemorrhage damage in 82 cases.Lesions were located in frontal lobe in 42 cases,14 lesions were located in temporal lobe,8 in occipital lobe,10 in frontoparietal lobe,8 in frontotemporal lobe,4 in parietotemporal lobe,26 in internal capsule of basal nodule,6 in thalamus,4 in brain stem,30 in subarachnoid cavity.12 patients exhibited multiple lesions.
-
颈动脉海绵窦瘘致颞叶出血和脑干淤血1例报告并文献复习
颈动脉海绵窦瘘(carotid cavernous fistula , CC F )是颈动脉或其分支与海绵窦之间形成的异常通道,血液经此通道由动脉直接流入海绵窦内[1]。CC F的常见症状有头痛、搏动性突眼、颅内杂音、球结膜充血、水肿、眼球运动障碍、蛛网膜下腔出血、耳鸣、鼻出血等,而眼外症状较少见。本研究报告1例CCF致颞叶出血及脑干淤血患者,结合文献复习,探讨其临床表现及形成机制,旨在为临床诊治该病提供经验。
-
小儿先天性颅内蛛网膜囊肿12例报告
本文报道12例小儿先天性颅内蛛网膜囊肿,幕上9例,幕下3例.早期手术预后良好.并介绍了该病的临床特点、诊断及治疗方法.