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理肠四方对溃疡性结肠炎大鼠结肠组织TNF-αmRNA表达的影响
目的:观察理肠四方对溃疡性结肠炎(UC)大鼠结肠组织细胞因子TNF-αmRNA的表达的影响,比较四方疗效大小,并分析其作用机制.方法:应用2,4-二硝基氯苯(DNCB)免疫加醋酸局部灌肠法建立UC大鼠模型,将98只健康SD大鼠(雌雄各半),按雌雄随机分7组,分别为乌梅丸组、白头翁汤组、参苓白术散组、痛泻要方组、柳氮磺胺吡啶(SASP)组、模型组和正常组,分别观察治疗后大鼠结肠黏膜TNF-omRNA的表达变化,并进行统计学比较.结果:造模后细胞因子TNF-αmRNA的表达升高(模型组与正常组平均吸光度比较P<0.01,t=4.128 vs正常组),理肠四方各治疗组、SASP组与模型组比较有显著意义(P<0.01,q=12.37vs乌梅丸组,q=9.52 vs白头翁汤组,q=8.79vs参苓白术散组,q=8.54 vs痛泻要方组,q=8.92 vsSASP组),但除乌梅丸外,理肠四方之间比较无明显差异.结论:经两两比较后,乌梅丸疗效好,白头翁汤、参苓白术散、痛泻要方与SASP组疗效相当.表明理肠四方可下调促炎细胞因子TNF-α,从而使溃疡性结肠炎大鼠免疫功能恢复正常,达到治疗的目的.
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AIM In order to provide the TCM therapeutic basis for MODS in clinical critical patients, the role of shockdecoction in anti-bacterial translocation from the gut was tested in rats.METHODS Based on the pathophysiology of MODS following bacterial translocation from the gut causedby severe injuries such as burn, shock, hemorrhagic shock model that induced obvious bacterial translocationwas established and used to determine whether shock decoction, that is composed of modified WenpiDecoction, reduces bacterial translocation. Bacterial culture for mesenteric lymph nodes, liver and spleen ofrats in shock, treatment and control groups was used to calculate the incidence of bacterial translocation.RESULTS The incidence of intestinal bacteria translocating to mesenteric lymph nodes, liver and spleenwas lower in the shocked rats infused via gastrogavage with shock decoction (3/ 15) than that in thenoninfused shocked rats (11 / 13), (P = 0.0009, < 0.01 ). The incidence of intestinal bacteria translocationof rats in shock and control groups were distinctly different (P = 0.0017, <0.01). The amounts and speciesof intestinal flora between infused and noninfused shocked rats were not different statistically (P=0.101,P>0.05). Histological examination showed that intestinal mucosa edema was severer in the shocked ratsthan in the shocked rats with gastrogavage.CONCLUSION Shock beverage could inhibit the shock-induced enterogenous bacterial translocation in ratsprobably by its protective role in intestinal mucosa structure; and has no effect on the growth of intestinalbacteria.
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CO2激光配合中药熏洗治疗尖锐湿疣58例
笔者在2006年8~10月间,采用中药配合应用JY-IIG型CO2 激光医疗机(西南技术物理研究所激光仪器厂生产)治疗尖锐湿疣58例,取得满意疗效,现报道如下.
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超临界二氧化碳萃取技术在中草药提取中的应用研究进展
超临界萃取(supercritical fluid extraction,SFE)[1~4]是上世纪30年代在国际上兴起的一种提取分离技术,近年来这种新型的萃取和分离技术逐步发展起来.它是利用超临界流体与其密度的溶解能力的关系,即利用压力和温度变化影响超临界流体溶解不同物质的能力而进行分离的方法.超临界流体具有和液体相近的密度,其黏度与气体相近,扩散系数为液体的10~100倍,因此对许多物质有较好的渗透性和较强的溶解能力.
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中药穴位敷贴治疗支气管哮喘的临床研究进展
支气管哮喘是一种以多种细胞特别是肥大细胞、嗜酸性粒细胞和T淋巴细胞等炎性细胞参与的气道慢性炎症和以气道高反应性(BHR)为特征的疾病病[1].20世纪60年代以来其发病率不断上升,目前全球患者已接近1.5亿,近20年来该病的防治方法一直是医药界探索的课题.糖皮质激素具有抗炎、抗过敏的强大作用,为西医治疗哮喘的首选药,但长期应用副作用明显,特别是对儿童[2].本病属中医哮证,清代医家张璐另辟蹊径,首创三伏天穴位敷贴药物防治哮喘,将穴位作用与药物作用有机结合,疗效独特.现代诸多医家对该疗法进行了临床观察与研究,兹将近20年来穴位敷贴防治支气管哮喘的进展综述如下.
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膝关节肿痛中药康复治疗1例
Background: Most middle-aged and aged patients with knee joints swelling and pain (knee joints degeneration is shown by X ray) are obese, the knee joints are chronically damaged by heavy load and much walk or extra exercises. According to the Chinese medicine theories: the middle-aged and the aged have weak liver and kidney, their sinews and bones are not well nourished, when damaged by too much labor, they are attacked by wind and moist and it is the main cause of the disease. Objective: To discuss the treating effects of Chinese herb on knee joints swelling and pain. Unit: Chinese Medicine Hospital of Huzhou City.
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李时珍猜谜识中药
在一个风雨交加的下午,李时珍采药避雨来到一条小船上.老渔翁和他的两个不到10岁的孙子热情地接待了他.老渔翁为李时珍端来吃的,李时珍也从包里拿出一瓶酒,招呼主人一齐坐下共酌.交谈了一会儿,老人对李时珍的身份便清楚了,老人把自己知道的药物知识全告诉了他.末了,老渔翁想起一个问题,说:"我们这里还有一种草药,能治身痒、癣疮."
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应用中草药环轮宁于小儿麻醉期间降压
中国科学院上海药物研究所自防己科植物地不容(Stephania epigeae Lu)中提取得到生物碱环轮藤宁(Cycleanine),经季铵化,成为二甲基溴化盐,称环轮宁,有明显降压作用(1),上海第二医学院附属新华医院麻醉科自1977年11月起应用环轮宁于小儿全麻期间控制性降压,效果满意,至1980年6月底已应用64例,报导如下
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微生态调节剂联合中药干预晚发型母乳性黄疸临床观察
随着母乳喂养率的提高,母乳性黄疸(BMJ)的发病率亦相应增高.据有关文献报道,晚发型母乳性黄疸可能存在胆汁瘀积[1,2].我们对2002年1月至2003年5月我院门诊和住院母乳喂养的60例晚发型母乳性黄疸血清胆红素(TBIL)和胆汁酸(TAB)含量进行了测定分析,并采用微生态调节剂联合中药综合疗法进行治疗,取得了较满意的效果.