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The Nogo receptor is an essential factor for neuronal apoptosis, but the changes in Nogo receptor expression in the retina and the effects of the Nogo receptor on retinal ganglion cell apoptosis in diabetes mellitus remain unclear. We found that Nogo receptor expression was mainly visible in retinal ganglion cells of a rat model of diabetes mellitus induced by streptozotocin. At 12 weeks after onset of diabetes mellitus, Nogo receptor and Rho kinase expression signiifcantly increased in the retina, and retinal ganglion cell apoptosis was apparent. When RNA interference was used to suppress Nogo receptor expression in rat retina, Rho kinase expression was obviously inhibit-ed, and retinal ganglion cell apoptosis was evidently reduced in rats with diabetes mellitus. These results indicate that upregulation of Nogo receptor expression is an important mechanism of retinal ganglion cell apoptosis in rats with diabetes mellitus.
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光动力疗法治疗脉络膜新生血管致视力下降病人的护理
脉络膜新生血管(CNV)可导致视力重度下降,从而影响病人的生活质量.光动力疗法(photodynamic therapy,PDT)可有效降低中度到重度视力丧失的危险,PDT治疗是将特异的光敏剂维替泊芬注入血管中,随血流到达眼底异常的新生血管,然后用一种特殊的非热能激光(冷激光)照射,从而破坏异常的新生血管,抑制各种新生血管的发展,从而保存视力的一种疗法.
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异体组织埋藏法改善视网膜色素变性
Background: Retinitis pigmentosa(RP) mostly harms sensitization organ and pigment epidermis . It is a progress and transmissible eye illness .It has severity harm to patients's eyesight.But now without specially cure. Objective: To introduce planting foreign tissue cure retinitis pigmentosa and appraise sight function.Design: we cure the patients with retinitis pigmentosa by planting foreign tissue. The patients have next one or two clinical symptoms. (1)Moon blindness;(2) Dwindle in vision field;(3)Retinal vas attenuate in evidence. Vas Choroid can been see cirrhosis.(4)The wave and wave's swing debases in retinal electricity chart.(5) Usually by heredity . After ,we value the visual acuity and visual field for treatment and aftertreatment , know that the complexion rejuvenate sight function.At one time, we confirm that planting foreign tissue is a valid method.
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复曲面软性角膜接触镜
角膜接触镜(contact lens,CL),特别是以聚甲基丙烯酸羟乙酯(polyhydroxyethyl methacrylate,HEMA)为主要原料生产的软性CL(soft CL,SCL),由于与框架眼镜相比具有视野开阔、像差小、像畸变轻等光学优势,较透气性硬镜(rigid gas permeablelens,RGP)配戴舒适,容易适应,配戴者逐渐增多[1,2].然而,为了提高透氧气(oxygen transmissibility,Dk/L)与舒适度,普通球面SCL(spherical SCL,SSCL)越做越薄、越做越软,其对散光的矫正能力越来越弱.据Holden(1975)统计,配CL者约有45%有0.75D以上的散光.据美国眼科协会CL分会1993年调查统计那些停戴SCL者约有20%是因为对矫正视力(corrected visual acuity,CVA)不满意,其中散光未能全部矫正是一个重要原因.美国CL理事会1991年调查发现,对CL有兴趣的配镜者约有1/3被其验配师告知因为他们的散光度数太高,不能配戴CL.长期以来,有许多人一直认为,SCL不能矫正散光[3].
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模拟快速上浮脱险训练对潜艇艇员对比视力的影响
自1962年英国首次采用快速上浮脱险技术以来,世界许多国家相继采用了这一技术,我国也对此进行了研究.目前快速上浮脱险已成为潜艇失事后艇员单人脱险的主要方式.笔者在实验室完成了潜艇艇员模拟快速上浮脱险训练,在训练中对脱险人员进行了对比视力(contrast visual acuity,CVA)和对比阈值的检查,并对检查结果进行了分析比较,为研究快速上浮脱险对艇员视功能的影响提供参考.
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WHO盲及视力损害分类新标准
在2009年世界卫生大会(WHA)上通过了WHO盲及视力损害的新标准[1],用"日常生活远视力(presenting distance visual acuity)",简称为"日常生活视力"代替既往标准"好矫正视力",并去掉了"低视力"的提法.
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准分子激光原位角膜磨镶术后连续性群发性DLK临床分析
0 引言准分子激光原位角膜磨镶术(laser in situ keratomileusis,LASIK)关键手术步骤是用微角膜切开刀做一定厚度的角膜瓣,弥漫性角膜基质炎(difffus lamellar keratitis,DLK)是发生于LASIK后早期角膜瓣下一种少见的并发症[1],目前认为DLK发病原因比较复杂,确切发病机制也不十分清楚,可以肯定为非感染性炎症,可能是角膜板层之间的一种非特异性过敏或毒性反应,术中抗原或毒素进入层间引起的急性反应.2006-06我院屈光手术中心在LASIK后连续3次发生群发性DLK,经数次全面排查确定为微角膜刀内铁锈清洗不干净所导致,累及16例28眼,其中有1眼产生角膜瘢痕而致佳矫正视力(best corrected visual acuity,BCVA)下降.现报道如下.