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INTRODUCTIONThe treatment of human epithelial malignancies is limited by drug resistance and toxic and side effects,which results in the failure in the treatment of majority of advanced cancer victims. To seek for a new, and specific antineoplastic therapy will provide hope for tumor treatment. Although disordered intermediary metabolism in cancer cells has been known for many years, much of the work focused on abnormal glucose catabolism. At the same time, little attention has been paid to fatty acid synthasis in tumor tissues, dispite of the significance of fatty acid synthase (FAS) in some clinical human ovarian[1], breast[2], colorectal[3],and prostatic cancers[4,5]. Tumor cells which express high levels of fatty acid synthesizing enzymes use endogeneously synthesized fatty acids for membrance biosynthesis and appear to export large amounts of lipid. In contrast, normal cells preferentially utilize diary lipid.
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可切除的梗阻性左半结肠癌的外科处理
20%~30%的左半结肠癌表现为急性肠梗阻(obstructed left colonic carcinoma,OLCC),是临床多见的急腹症.OLCC的术中处理方式多样,能否针对患者的具体情况、医师的技术和所在医院的条件选择恰当的处理方式,将可能给患者带来完全不同的结局.可以说,在目前特定的医患关系下,每一例可切除的OLCC的处理是外科医生胆识和对患者情况把握能力的一次考量.
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胸腹联合CT增强扫描技术在大肠癌患者中的运用
我院是全国中医肛肠诊疗中心,每年有大量大肠癌患者需要进行胸腹CT增强扫描对疾病进行术前诊断和术后监测,以观测肿瘤有无转移及转移病灶的具体状况,为明确手术指征以及进一步治疗提供帮助.
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结肠癌复发的种类、原因及预防
肿瘤的复发是指癌肿治愈性切除后,又长出和原来同样性质的肿块及由此而产生的症状.然而目前对复发概念的认识相当模糊,常将非治愈性切除病例,甚或姑息性切除病例残留病灶的发展增大也当成是肿瘤的复发.
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右半结肠联合胰十二指肠切除治疗结肠癌两例
2005年笔者为2例累及十二指肠和胰腺局部的晚期结肠癌(local advanced colonic carcinoma,LACC)患者实施了右半结肠联合胰十二指肠切除,随访效果满意.