首页 > 文献资料
-
经皮穴位电刺激诱发的大脑fMRI信号与镇痛的关系
针刺主要是通过激发内源性阿片达到镇痛的目的.不同个体针刺镇痛效果的差异,与胆囊收缩素(CCK)等抗阿片物质的个体水平有关,那么,CCK是通过何种通路来影响针刺镇痛的呢?我们应用功能性磁共振成像(fMRI)针对这个问题进行了研究.实验采用两种频率(2 Hz,100 Hz)的经皮穴位电刺激(TEAS)模拟针灸的不同手法,其优点是镇痛效果肯定,刺激参数可以量化.以前的研究表明,不同的脑内神经通路分别介导低频和高频TEAS镇痛,中脑、丘脑和下丘脑的某些核团起着关键性的作用.
-
Objective: To explore the strengthening of acupuncture analgesic mechanism on the level of β-endorphin and proopimelanocortin mRNA expression in the arcuate nucleus of hypothalamus in rats following electroacupuncture(EA) combined with melatonin (MEL). Methods: Integrated optical density (IOD) was measured by ABC immuno-histochemical and in situ hybridization technique with computerized image processing. The rat's brain was coronally sectioned after combination of EA and MEL. Results: IOD of β-endorphin-like immunopositive substance in rat's brain was lowered significantly, which was measured after MEL (60 mg/kg) was injected intraperitoneally and followed by EA 30 min later for 30 min, and the IOD of cerebral POMC mRNA positive substance increased significantly 10 hrs later. Conclusion:The mechanism of MEL in enhancing EA analgesic effect might be related with the release and synthesis of β-endorphin
-
经阴道穿刺取卵术中不同方法镇痛效果比较
随着不孕症发病率的增加和体外受精-胚胎移植(in vitro fertilizatioa-embryo transfer,IVF-ET)技术的不断成熟,通过IVF-ET技术成功妊娠的病人日益增多.经阴道穿刺取卵术作为IVF-ET过程中重要的一环,同时也是病人承受痛苦大的一环.如何在取卵术中减轻病人痛苦,减少副反应的发生,是医务工作者的职责.目前,国内应用较多的有静脉麻醉、宫颈麻醉、哌替啶肌肉注射等方法.哌替啶镇痛因费用低廉、镇痛效果好、无需麻醉师参与等优势在经阴道穿刺取卵术中应用广泛.近年来,双氯芬酸钠栓因镇痛效果好、价格低廉、副反应少且使用方便被广泛应用于临床镇痛治疗.2010年1月-2010年12月,我院在经阴道穿刺取卵术中应用哌替啶肌肉注射及双氯芬酸钠栓直肠用药两种方式镇痛,比较两种方案镇痛效果及副反应发生情况.现报道如下.
-
小剂量曲马多用于膝关节镜术后镇痛效果比较
Objective To investigate analgesic effect of intra-articular low-dose tramadol after arthroscopic knee surgery.Methods 60 patients undergoing arthroscopic knee surgery under lumbar anesthesia were randomly divided into intra-articular injection of tramadol(TJ group),mulscle injection of tramadol(TM)and saline control group.Vision analog scoring was conducted under extension of knee joint 8h and 24h after drugs administration.Follow-up was done to observe unwanted effects 48h after surgery.Results Score of TJ group was significantly lower than those of other groups(P<0.05).No unwanted effects were found.Conclusion Intra-articular tramadol in low-dose could relieve operative pain.
关键词: 小剂量 多用 膝关节镜 Analgesic Effect knee joint -
阿替卡因肾上腺素与利多卡因在口腔治疗中镇痛效果的比较
无痛治疗是现代治疗口腔科重点研究的方向之一,局麻药原来广泛使用2%利多卡因注射液局部浸润和阻滞麻醉,麻醉效果欠佳,患者恐惧而延误了佳治疗时间,阿替卡因肾上腺素注射液是一个新型酰胺类口腔专用局麻药,药理特点是麻醉起效时间快,持续时间长,麻醉力强,在体内容易降解,毒性作用小.包装是卡集式,抗高压型,完全适应口腔解剖特点,是口腔局部麻醉专用注射器,配套使用一次性消毒针头细小,可减少注射点粘膜的疼痛.