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八肽胆囊收缩素对抗电针对大鼠尾核痛反应神经元电活动和甩尾痛阈的同时影响
许多资料表明,八肽胆囊收缩素(CCK-8)能对抗阿片物质的镇痛作用.实验用雄性Wistar大鼠30只,用20%氨基甲酸乙酯(1.0 g/kg体重)麻醉下实施常规手术.以辐射热照射大鼠尾部作为伤害性刺激,用玻璃微电极引导尾核中痛反应神经元放电.本实验以大鼠尾核中痛兴奋神经元(PEN)和痛抑制神经元(PIN)的电变化及甩尾反射潜伏期(TFL)三者为指标,研究了脑室注射15 ng CCK-8对抗电针对尾核痛反应神经元放电和甩尾痛阈的同时作用.
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AIM We have discovered that Limonene modulates interdigestive myoelectrical complexes (IMCs) ofgastrointestinal tract in rats. In this research we will elucidate weather limonene affects acetylcholine M-receptor in caudate nucleus.METHODS Changes of IMCs were studied after limonene and/or atropine were microinjected into caudatenucleus. IMCs were recorded by a RM-6200 four-channel recorder and then delivered to Maclab and PowerMacintosh.RESULTS The active phases of IMCs occupied about 40% of total cycle in average. After microinjection oflimonene into caudate nucleus, the active phases were significantly shortened, while the cycle time of IMCswere not changed significantly. The inhibitory effects of limonene were abolished by pretreatment withatropine, whilst the atropine has no effect on IMCs.CONCLUSION It is suggested that limonene inhabits the gastrointestinal IMCs by affecting M-receptor incaudate nucleus.
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大鼠尾核多巴胺受体抑制对黑质升压作用的影响
-纹状体多巴胺系统是中枢多巴胺系统的重要组成成分.资料表明,谷氨酸钠微量注入及电刺激黑质(substantia nigra,SN)均可使血压升高,幼年自发性高血压大鼠(spontaneously Hypertensive Rat,SHR)脑室注射6-羟多巴胺使额皮质和尾状核中DA下降,并能削弱SHR高血压的发展,电解损毁黑质使SHR血压升高延迟,这提示黑质DA能神经元可能通过中枢机制发挥其升压作用,并可推测黑质-纹状体DA系统在高血压发展中起作用.
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尾状核头部出血的诊断问题探讨
在急性出血性脑血管疾病中, 基底节区出血是常见的一种类型, 其中以壳核及丘脑部位出血为多见, 而尾状核头部出血较少见[1], 临床上单纯根据病史和体征很难作出正确诊断, 或经常被误诊为蛛网膜下腔出血, 自从CT用于临床, 对其有了新的认识. 现将我们收治的20例尾状核头部出血分析如下.