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一例Wilson病的影像学表现
Introduction Wilson's disease is a rare inherited disorder of copper metabolism which is characterized by the inability to secrete the copper-ceruloplasmin complex into plasma and free copper into the bile.In the liver,the copper deposits in the periportal regions and incites an inflammatory reaction, resulting in chronic liver disease[1].
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Small rodent models of hepatitis B and C virus replication and pathogenesis
The narrow host range of infection supporting the long-term propagation of hepatitis B and C viruses is a major limitation that has prevented a more thorough understanding of persistent infection and the pathogenesis of chronic liver disease (CLD).With hepatitis B virus (HBV),this has been partially overcome by the discovery and characterization of HBV-like viruses in wild animals.With hepatitis C virus (HCV),related Fiaviviruses have been used as surrogate systems for such studies.Independent work has developed various mouse strains for the transplantation of human hepatocytes,which are then susceptible to infection with HBV and HCV.Other laboratories have developed transgenic mice that express virus gene products and/or support virus replication.Some HBV transgenic mouse models develop fulminant hepatitis,acute hepatitis,or CLD following adoptive transfer,while others spontaneously develop hepatocellular carcinoma (HCC),as in human infections.Among HCV transgenic mice,most develop no disease,but acute hepatitis has been observed in one model,while HCC appears in another.Other mouse models include the introduction of xenographs that replicate HBV or HCV.Although mice are not susceptible to these viruses,their ability to support virus replication and to develop liver disease characteristic of human infections,provides new opportunities to study pathogenesis and develop novel therapeutics.
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慢性肝病血管新生研究
慢性肝病血管新生是导致肝硬化和肝硬化门静脉高压的重要因素.血管新生增加肝内血管阻力和减少有效肝细胞灌注,导致慢性肝病进展为肝硬化;另一方面血管新生调控门-体侧支循环的形成,增加内脏血流量,导致肝硬化门静脉高压及其并发症的发生.
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慢性肝病的生命质量量表评价
生命质量研究是随着人群健康改善情况逐渐发展起来的一种健康测量技术,作为患者躯体功能、心理状态、社会适应和环境因素指标的一种反映,能全面体现患者健康水平.生命质量正是在这种客观健康水平提高和主观健康观念更新的背景下应运而生的一套评价健康水平的指标体系.
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抗核抗体与抗线粒体抗体在慢性肝病诊治中的意义
自身抗体是由于各种原因造成机体B淋巴细胞产生的针对自身组织成分的抗体.随着对自身免疫性疾病的深入研究,大量的自身抗体被发现,其中一些自身抗体被公认为某种疾病的标志性抗体,而大部分自身抗体与疾病的相关性还有待进一步积累临床资料和作深一步的研究.