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神经病理痛的诊断及分类
神经病理痛的流行病学及影响根据NeuPSIG(神经病理痛特别兴趣组,Spe-cial Interest Group on Neuropathic Pain)的定义,神经病理痛是一种由躯体感觉系统受损或病变直接导致的疼痛,已经成为健康的一大难题.然而,这种常见的疼痛类型却常常得不到诊断或治疗不足,并且造成痛苦、残疾,生活质量下降以及大量的花费.
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What Makes a Good Doctor?
Introduction In the United States and I suspect in all parts of the world, a good doctor is an individual who, in addition to training in their area of interest, i.e., family practice, internal medicine, or a subspecialty area, has participated actively in the educational programs relating to their training which make them eligible to take examinations in those areas (if they are available) and pass them.All physicians generally like to have some procedural skills,but the most important part of their skills relate to their cognitive knowledge which in the long term insures optimal patient care.
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步入21世纪的断层图像重建[从不完全数据重建感兴趣区]
从投影重建图像是“计算机断层成像(CT)”立论的基础.几十年来,它所确立的原理不仅应用在放射科和核医学的医用扫描装置,也用于工业扫描系统.当论及从投影重建图像时,人们一般考虑的是这样的问题:根据若干沿直线的测量值来恢复某些密度函数,或简称“线积分模型”.
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Anesthetic-Induced Developmental Neurotoxicity
1 IntroductionMillions of newborn and infants receive anesthetic,sedative and analgesic drugs for surgery and painful procedures on a daily basis.Recent laboratory reports clearly demonstrate that anesthetic and sedative drugs induced both neuroapoptosis and neurocognitive deficits in laboratory models.This issue is of paramount interest to pediatric anesthesiologists and intensivists because it questions the safety of anesthetics used for fetal and neonatal anesthesia[1-2].In an attempt to summarize the rapidly expanding laboratorybased literature on anesthetic-induced developmental neurotoxicity (AIDN),this review will examine published reports on the characterization,mechanisms and alleviation of this phenomenon.
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根据INTETREST试验结果分析预测吉非替尼和多烯紫杉醇对非小细胞肺癌患者疗效的生物学标志物
1 文献来源Douillard JY,Shepherd FA,Hirsh V,et al.Molecular predictors of outcome with Gefitinib and Docetaxel in previously treated non-small-cell lung cancer:Data from the randomized phase Ⅲ INTEREST trial[J].J Clin Oncol,2010,28(5):744-752.
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来自大型Ⅲ期随机临床研究INTEREST的数据
INTEREST研究是一项大型Ⅲ期随机对照临床研究,总计1446例既往接受过化疗的晚期非小细胞肺癌(nonsmall cell lung cancer,NSCLC)患者随机接受非替尼或者多西此杉醇治疗,预先设定的肿癌组织生物标志物与临床疗效相关性分析结果发表于2009年后一期< Journal of Clinical Oncology>杂志上.
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Pediatric Clinical Pharmacology and Child Health:A Canadian Perspective
IntroductionCanadian academic centres and children's hospitals have had a longstanding interest in the improvement of drug therapy for children through research conducted across the four pillars of activity identified as being of critical importance by the Canadian Institutes of Health Research(viz,basic research,clinical research,population health research,applied health and policy research)[1].