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走出痛风性关节炎诊断和治疗的误区
近20年,国内许多医院相继建立了血清类风湿因子和人类白细胞抗原(HLA)-B27的检测方法,尽管它们为临床诊断提供了参考依据,但也带来一些负面影响.尤其明显的是,一些医师不问其他,简单地将类风湿因子阳性或HLA-B27阳性者诊断为类风湿关节炎或强直性脊柱炎,于是造成了对一些患者的误诊和误治.与上述现象同出一辙的是,许多医师也简单地将血尿酸增高等同于痛风,或对急性发作的痛风性关节炎(gouty arthritis)患者给予别嘌醇治疗,而且这种误诊误治的现象屡见不鲜.为此,有必要呼吁医务人员应对发病率日益增加的痛风性关节炎的诊断和处理提高认识,走出误区,规范治疗,防治结合.
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中药封包辅助治疗急性痛风性关节炎效果观察
急性痛风性关节炎是尿酸盐结晶在关节周围沉积引起的急性疾病,多表现为单个跖趾关节猝然红肿、疼痛,以第一跖趾关节多见,痛势剧烈,夜间尤甚,可伴有发热,常因进食高嘌呤食物而诱发[1,2].随着经济发展和人们生活方式改变,患病率逐年上升,传统药物治疗对本病有一定的疗效,但不良反应较多.鉴此,2008年1月-2010年10月笔者采用中药局部封包辅助治疗急性痛风性关节炎病人42例,疗效较好.现报告如下.
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骨关节疾病康复期治疗体会
Osteoarthropathy is classified as rheumatoid arthritis,specific infective arthritis,osteoarthritis(degenerative joint disease)and gouty arthritis.How to guide patients to exercise joint function is very important to rehabilitation of kinds of arthritis.
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中西医并治急性期痛风性关节炎关节红肿痛120例
Background:The acute gouty arthritis causes painful joints and obvious swelling. Sometimes it also causes liquid in joints. The joints are so painful that touch is resisted, it has trouble to curve and extend and the function is greatly hampered. Also fever, palpitation and fatigue are caused. Most cases are in fat people with good diet. The incidence is greatly increased with the development of living condition in recent years and male cases are more than female cases (about 20:1). Purine and colchinine cause slow effect and serious side effects. We began to treat it with Chinese medicine combined with western medicine from 1998 and gained some experience
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低嘌呤饮食对痛风性关节炎疗效的影响
痛风是由于嘌呤代谢障碍引起持续性血尿酸增高造成组织损伤的一组异质性疾病,其中病因与患者饮食生活习惯有密切的关系.本文对38例痛风性关节炎在临床症状、治疗基本相同的条件下,应用低嘌呤饮食治疗和自由选食进行随机对照,研究不同嘌吟含量的饮食对患者血尿酸及临床症状的影响,报告如下.
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Creatinine, uric acid, hypoxanthine and xanthine are important diagnostic biomarkers in human urine for gouty arthritis or renal disease diacrisis. A simple method for simultaneous determination of these biomarkers in urine based on reversed-phase high-performance liquid chromatography (RP-HPLC) with ultraviolet (UV) detector was proposed. After pretreatment by dilution, centrifugation and filtration, the biomarkers in urine samples were separated by ODS-BP column by elution with methanol/50 mM NaH2PO4 buffer solution at pH 5.26 (5:95). Good linearity between peak areas and concentrations of standards was obtained for the biomarkers with correlation coefficients in the range of 0.9957-0.9993. The proposed analytical method has satisfactory repeatability (the recovery of data in a range of creatinine, uric acid, hypoxanthine and xanthine was 93.49-97.90%, 95.38-96.45%, 112.46-115.78%and 90.82-97.13%with standard deviation of o5%, respectively) and the limits of detection (LODs, S/N Z 3) for creatinine, uric acid, hypoxanthine, and xanthine were 0.010, 0.025, 0.050 and 0.025 mg/L, respectively. The established method was proved to be simple, accurate, sensitive and reliable for the quantitation of gouty arthritis' biomarkers in human urine samples. The ratio of creatinine to uric acid was found to be a possible factor for assessment of gouty arthritis.