Prenatal alcohol exposure disrupts the development of normal fetal respiratory function, but whether it perturbs respiratory rhythmical discharge activity is unclear. Furthermore, it is un-known whether the 5-hydroxytryptamine 2A receptor (5-HT2AR) is involved in the effects of prenatal alcohol exposure. In the present study, pregnant female rats received drinking water containing alcohol at concentrations of 0%, 1%, 2%, 4%, 8% or 10% (v/v) throughout the gestation period. Slices of the medulla from 2-day-old neonatal rats were obtained to record respiratory rhythmical discharge activity. 5-HT2AR protein and mRNA levels in the pre-B?tzing-er complex of the respiratory center were measured by western blot analysis and quantitative RT-PCR, respectively. Compared with the 0% alcohol group, respiratory rhythmical discharge activity in medullary slices in the 4%, 8% and 10% alcohol groups was decreased, and the reduc-tion was greatest in the 8% alcohol group. Respiratory rhythmical discharge activity in the 10%alcohol group was irregular. Thus, 8% was the most effective alcohol concentration at attenuating respiratory rhythmical discharge activity. These ifndings suggest that prenatal alcohol exposure attenuates respiratory rhythmical discharge activity in neonatal rats by downregulating 5-HT2AR protein and mRNA levels.

慢性阻塞性肺疾病患者IL-8IL-10与呼吸功能的相关性分析

慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)的发病机制复杂,其中细胞因子在其发病中的作用是近年来研究的热点之一.目前认为白细胞介素8(Interleukin-8,IL-8)在COPD的发病中起重要作用[1].

开胸手术后呼吸功能训练的疗效分析

Objective To investigate effect of respiratory training on respiratory function recovery following thoracotomy. Method Respiratory muscle training, productive drainage, exercise and respiratory function training, and appropriate rehabilitation were performed on 216 patients underwent thoracotomy. Result 206 patients showed favorable recovery of respiratory function,7 showed respiratory dysfunction, and 1 developed serious complication. Conclusion Respiratory training after thoracotomy significantly improve respiratory function.

腹部手术对呼吸功能的影响

手术后的肺部并发症是导致围手术期病死率增加的重要原因.在接受腹部手术的病人,肺部并发症远较心脏异常更为普遍,其患病率平均约为30%[1～5].

不同浓度布比卡因高位硬膜外阻滞对肺通气功能的影响

高位硬膜外阻滞已广泛应用在乳腺癌根治术、甲状腺癌颈部淋巴结清除术及双上肢等多类手术中.但高位硬膜外阻滞易致膈神经和肋间神经阻滞,影响肺通气功能和呼吸方式,故其安全性备受关注.以0.375%布比卡因高位硬膜外阻滞可引起PaCO2上升[1],SpO2明显下降[2],其危险性显著增加.多少浓度布比卡因用于高位硬膜外阻滞适宜呢?为此,本研究以0.25%与0.125%两种浓度布比卡因进行比较,旨在探讨两者对肺通气功能的影响.

强化麻醉对小儿呼吸功能的影响(附30例血气分析)

我院自1971年以来,对于小儿各种手术(包括开胸)采用了强化基础麻醉共3,000多例.为了确切地观察强化麻醉对小儿呼吸功能的影响,以便采取有力措施,进一步提高手术的安全性.我们对性别、年龄、病情均无选择的30例病儿,于麻醉前、后采用微量血液气体分析方法作了呼吸功能测定,现将其结果报道如下.

Objective:To analyze the effect that right dexmedetomidine for anesthesia induction period on the hemodynamics and respiratory function in patients undergoing radical resection of esophageal carcinoma.Methods:120 cases patients of esophageal carcinoma radical resection were randomly divided into observation group and control group and 60 cases in each group, the control group was given conventional anesthesia and intravenous infusion of normal saline, and the observation group was given routine anesthesia and intravenous infusion of right dexmedetomidine. Compared two groups patient’s hemodynamics and respiratory function changes before induction of anesthesia (T0), after induction 10 min (T1), during intubation (T2), after intubation 30 min (T3), after extubation 30min (T4) at each time point.Results:(1) The observation group’s MAP of T1, T2, T3 and T4 were significantly lower than the T0. The control group’s MAP of T1, T3, T4 were significantly lower than the T0, and lower than the same period of the observation group, but T2 was significantly higher, it’s higher than the T0 and the same period of the observation group, The difference was statistically significant;The observation group and control group’s HR of T1, T3, T4 were significantly lower than the T0, and T2 increased, there were obvious than the observation group that the T1, T3, T4HR reduced, and T2 increased of the control group, so the difference was statistically significant, The dynamic curve change of HR and MAP in the observation group was less than the control group; (2)The observation group’s RR of T0, T1, T2, T3, T4 were stable, and there was no significant difference in the time period, There was significant difference in the RR of the control group at each time period, T2 was significantly higher than T0, and higher than the same period of the observation group, T3, T4 significantly lower than T0, and lower than the same period of the observation group, the difference was statistically significant; The SpO2 of T0 ,T1, T2, T3, T4 in the observation group were stable, and there was no significant difference in the time period, the control group T2, T3, T4 SpO2 significantly lower than T0, and lower than the same period of the observation group, the difference was statistically significant, T2 especially significant, the dynamic curve change of RR and SpO2 in the observation group were less than the control group.Conclusion:Right dexmedetomidine will help to improve the stability of the hemodynamic and respiratory function during induction of anesthesia in patients with radical resection of esophageal carcinoma.