Objective:To analyze the effect that right dexmedetomidine for anesthesia induction period on the hemodynamics and respiratory function in patients undergoing radical resection of esophageal carcinoma.Methods:120 cases patients of esophageal carcinoma radical resection were randomly divided into observation group and control group and 60 cases in each group, the control group was given conventional anesthesia and intravenous infusion of normal saline, and the observation group was given routine anesthesia and intravenous infusion of right dexmedetomidine. Compared two groups patient’s hemodynamics and respiratory function changes before induction of anesthesia (T0), after induction 10 min (T1), during intubation (T2), after intubation 30 min (T3), after extubation 30min (T4) at each time point.Results:(1) The observation group’s MAP of T1, T2, T3 and T4 were significantly lower than the T0. The control group’s MAP of T1, T3, T4 were significantly lower than the T0, and lower than the same period of the observation group, but T2 was significantly higher, it’s higher than the T0 and the same period of the observation group, The difference was statistically significant;The observation group and control group’s HR of T1, T3, T4 were significantly lower than the T0, and T2 increased, there were obvious than the observation group that the T1, T3, T4HR reduced, and T2 increased of the control group, so the difference was statistically significant, The dynamic curve change of HR and MAP in the observation group was less than the control group; (2)The observation group’s RR of T0, T1, T2, T3, T4 were stable, and there was no significant difference in the time period, There was significant difference in the RR of the control group at each time period, T2 was significantly higher than T0, and higher than the same period of the observation group, T3, T4 significantly lower than T0, and lower than the same period of the observation group, the difference was statistically significant; The SpO2 of T0 ,T1, T2, T3, T4 in the observation group were stable, and there was no significant difference in the time period, the control group T2, T3, T4 SpO2 significantly lower than T0, and lower than the same period of the observation group, the difference was statistically significant, T2 especially significant, the dynamic curve change of RR and SpO2 in the observation group were less than the control group.Conclusion:Right dexmedetomidine will help to improve the stability of the hemodynamic and respiratory function during induction of anesthesia in patients with radical resection of esophageal carcinoma.