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血栓通对脑梗死患者神经功能恢复的疗效观察
Background:Xueshuantong is extracted from dried root of Panax notoginsen,its functioning elements is general saponin. Modern medical science indicates Xueshuantong is capable of inhibiting platelet aggregation, enhancing fibre lytic ability, elongating prothrombin time and clotting time, promoting metamorphotic ability and oxygen carrying ability of red cells, relieving blood vasospasm, improving microcirculation, supplementing blood flow and anticoagulation,accelerating thrombolysis and preventing thrombosis. Objective:To observe effect of Xueshuantong on functional recovery of nerves in patients following brain infarction.
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Effects of Dynamic Wall Properties on Blood Flow in Stenotic Arteries
High grade stenoses may cause critical flow and mechanical conditions such as negative pressure, flow separation,high shear stress and wall compression in arteries which may be related to platelet aggregation, thrombus formation, atherosclerosis growth and plaque cap rupture which leads directly to stroke and heart attack. The exact mechanism of these events and the conditions causing them are not well understood. Blood flow is highly pulsatile.
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剪应力对血管内皮细胞与血小板形态功能的影响
1 导言 近二十年来的研究证实血管内皮不仅是机体重要的屏障和半透膜,而且还是机体重要的代谢和内分泌器官。血管内皮细胞(Vascular Endothelial Cells,VEC)可以合成和释放几十种生物活性物质,在抗血栓形成、止血、物质转运、血管张力调节等方面起重要作用;在循环系统局部稳态维持、机体自身防病机制中扮演了非常重要的角色。而一直作用于内皮的血液流动剪应力对内皮细胞(EC)形态及功能的改变起重要作用。本文从剪应力依赖的EC功能及其影响剪切诱导血小板聚集(Shear Induced Platelet Aggregation,SIPA)方面做综合性论述。
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剪切诱导血小板聚集及其机理研究
导言在动脉血栓性疾病的病理过程中,血小板活化是重要的始动因素.有许多物质,如凝血酶、肾上腺素等可导致血小板的活化和聚集.近年来研究发现,血流中单纯的高剪切应力也可以诱导血小板聚集.这不但对于存在高剪切应力的血管,如小动脉,动脉痉挛和动脉硬化造成的局部狭窄区的血栓形成有特别重要的意义,还可在其下游形成微血栓,堵塞微血管,造成微循环障碍.因此,研究剪切诱导血小板聚集(Shear induced platelet aggregation,SIPA)的机理有十分重要的意义.
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16袋新鲜机采血小板聚集原因分析
血小板输注可用于预防和治疗因血小板降低或血小板功能缺陷而引起的出血.自血小板单采技术广泛应用以来,凭借其高浓度和高纯度的特点,深受临床患者欢迎.欧美国家有70%~80%的临床输注血小板制品均来源于单采.我国无偿献血起步较晚,单采血小板制品的临床应用量却也以每年20%~30%的速度递增[1].