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在椎间盘突出物或椎间盘内注射胶原酶对椎间盘突出症治疗作用的研究
Objective To compare effect of chemonucleolysis of collagenase injected intraprotrusion(disc protrusion) with intradisk (disc centre ) at the affected disc guided by computer scan(CT) on lumbar disc herniation. Method 156 patients were randomly divided into two groups.Repeat CT shows guided 1200 U collagenase intraprotrusion or intradisk injection of the affected disc via extradural or intradual way for the patients.3 month follow up was performed to evaluate the therapeutic effect.Result The observation indicated that the patients showed no any seriously side effect.The effective rate was 86% for intraprotrusion injection and 71% for intradisk injection respectively.χ 2 test demonstrated the difference was significant(χ 2=5.3969).Conclusion Guided under CT, intraprotrusion injection with collagenase at the affected disc is safe,more effective treatment than that of intradisk injections for lumbar disc herniation.