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理气中药对鼠胃肠动力的影响
目的:观察理气中药促胃肠动力作用及作用机制.方法:观察10种理气中药对健康小鼠服药前后胃内残留率及小肠推进率的变化;以大鼠腹腔注射L-Arg造成的大鼠胃肠运动障碍模型为对象,探讨木香及大腹皮对模型大鼠胃肠运动及胃动素、NO的影响.结果:理气中药中大腹皮、陈皮、砂仁、厚朴、木香对健康小鼠胃残留率明显低于对照组;陈皮、大腹皮、枳实、砂仁、苦楝子、香附对正常小鼠小肠推进率明显高于对照组(P<0.05);大腹皮、木香对造模大鼠用药后胃动素较造模组显著升高(P<0.05);大腹皮使造模大鼠血中一氧化氮显著下降(P<0.05).木香、大腹皮能显著改善造模大鼠的胃排空(P<0.05),且与西沙必利间无明显差异(P>0.05).结论:理气中药木香、大腹皮、砂仁、厚朴、陈皮有明显的促进胃排空作用;木香、大腹皮作用明显强于砂仁、厚朴、陈皮;木香的作用优于西沙必利.枳实、大腹皮、陈皮、香附、砂仁、苦楝子有促进小肠传输功能.木香、大腹皮能明显改善L-Arg所致胃排空障碍.木香、大腹皮对L-Arg所致小肠传输功能障碍无改善作用.
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复方中药健脾丸和保和丸对小鼠胃肠运动的影响
目的:观察传统的消食导滞方剂保和丸和健脾丸对小鼠胃肠运动功能的影响.方法:以胃肠内标记物葡聚糖蓝-2 000在胃内色素残留量及小肠推进比为指标,观察各实验组对正常脾虚模型小鼠胃排空及肠推进的影响.结果:保和丸、健脾丸对正常小鼠及脾虚模型小鼠的胃排空均走到明显的促进作用0.029±0.033 vs 0.059±0.035;0.018±0.010 vs 0.059±0.035;0.036±0.028 vs 0.089±0.042;0.029±0.026 vs 0.089±0.042.(P<0.05);对正常小鼠的肠推进运动的促进作用,保和丸则更优于健脾丸58.8±11.3 vs 51.6±9.7,(P<0.05).对肠蠕动功能增强的"脾虚"模型小鼠的肠推进运动,保和丸仍有促进作用63.5±6.1 vs 54.1±12.3,(P<0.05),而健脾丸则可调节使其减慢而恢复正常43.0±7.1 vs 54.1±12.3,(P<0.05).结论:保和丸及健脾丸对胃肠运动功能可起到促进及调节作用.
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The polyamines [putrescine (PU), spermidine (SPD) and spermine (SPM)] are ubiquitous polycationiccompounds found in all prokaryotic and eukaryotic cells, are essentially involved in a variety of regulatorysteps during normal, adaptive, and malignant cell proliferation. Nearly four decades investigation about thepolyamines contributed to the synthesis and decomposition of polyamines and the active and passive enzymeswhich regulate them at different levels. This review focuses on the sources and homeostasis of intracellularpolyamines, the transport and role of the polyamines in the growth of the gastrointestinal mucosa and theirpossible mechanism. We tried to point out the gaps remaining in the story and give a working hypothesis forthe role of polyamines in gastrointestinal mucosal growth. We propose in the hypothesis that polyamine is a“key”to unlock the “door”of cell proliferation. How many “doors” between the “polyamine key” and the“real start” of proliferation? The polyamine might be the only key for cell proliferation. Another possibilityis that polyamine is the first key and its “unlocking-effect” resulting in getting another key for the next doorin the proliferation chain, for example, proto-oncogenes. To decide whether polyamine is an intermediatestep or just only one step of cell proliferation, the possible way is to keep polyamine to be a stimulus and finda way to deprive the function of proto-oncogene protein (or other possible gene expression product) to checkthe effect on the cell proliferation. Another important question is how polyamine can trigger the synthesis ofDNA in virtual. Arabinose operon model may give us some ideas to investigate about that. And furthermore,it is necessary to pay attention to the relationship between polyamine and other cell proliferation regulator,like growth factor, chalone, cAMP, cGMP, etc. Further studies are needed to investigate the mechanism ofpolyamine acted on the gastrointestinal mucosal growth.
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小儿急性假性肠梗阻
性肠梗阻(intestinal pseudo-obstruction,IPO)系肠道肌肉神经病变引起的胃肠动力疾病(disorders of gastrointestinal motility, DGIM)[1]之一,由肠肌病或肠神经病导致异常收缩活动,在发作期或慢性期有类似机械梗阻表现,但缺乏机械性肠梗阻证据.
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第二届全国小儿胃肠动力学术会议纪要
由<中华儿科杂志>编辑委员会和中华医学会儿科学分会消化学组共同主办的"第二届全国小儿胃肠动力学术会议"于2008年9月20-23日在湖南省张家界市召开.
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胃肠功能性和动力紊乱性疾病研究现状与展望
上个世纪的后四分之一年代,人们对以腹痛、腹胀、早饱、吞咽困难、反酸、胃灼热、呃逆、嗳气、恶心、呕吐及排便异常等临床常见的消化系症状的研究,无论从病理生理学、实验诊断学、乃至治疗学方面的研究都得到了长足的发展.由于评价胃肠道电活动和动力学各个方面的问题研究大大地扩展了人们对胃肠道活动机制的理解.对于动力学从分子到整体器官水平、从器官到整个消化系统的研究也使得临床在对付胃肠功能性疾病(functional gastrointestinal disorders, FGID)和胃肠动力紊乱性疾病(disorders of gastrointestinal motility, DGIM)有了许多新的药物.人们有理由相信,在社会节奏的日益增快、竞争压力日渐增强、传统的生活习惯逐渐变化的今天,虽然这类疾病在人群中的发生有日益增高的趋势,有时甚至严重的困扰着人们,但随着大量研究工作的进展,对它的治疗终会获得更好、更加有效的办法.
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成纤维样细胞和小电导钙激活钾通道3在调节胃肠平滑肌活动中的作用
功能性胃肠病(functional gastrointestinal disorders,FGID)和胃肠动力性疾病(disorder of gastrointestinal motility,DGIM)是临床常见病多发病,胃肠器质性疾病以及一些全身疾病如糖尿病、尿毒症等,亦可伴有胃肠运动异常.胃肠运动的调节异常是其病理生理基础.近年来发现的成纤维样细胞(fibroblast-like cell,FLC)、小电导钙激活钾通道(small conductance Ca2+ -activated K+claannels,SK)3亚型在调节胃肠平滑肌活动中有一定作用,为胃肠动力异常的研究提供新的思考.
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胃肠功能和动力障碍研究进展
近年提出的功能性胃肠病(FGID)的罗马Ⅱ诊断标准和胃肠动力障碍(DGIM)的新分类[1,2]已为国内外普遍接受,并有助于国内外的交流.这里将讨论FGD和DGIM的研究热点、方法学及诊治的进展.
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雌激素对胃肠动力的影响
胃肠动力障碍性疾病是一组胃肠综合征的总称,临床主要表现为胃肠道的症状,以食欲小振、腹痛、腹胀、恶心、呕吐、腹泻及排便困难等症状为主要表现,可伴有其他功能性症状,具体病因不清,严重影响人们的身心健康.近年来关于雌激素及其受体对消化道动力的研究倍受重视,并取得了一定进展,本文就雌激素及其受体对?肖化道动力影响进行综述.