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唐氏综合征产前筛查模式的发展
21世纪初以来,国外通过完成一系列的多中心、大样本、前瞻性的研究来评价中孕期及早孕期各种不同筛查模式,为临床医生及孕妇选择为适宜的产前筛查模式提供确实的依据.其中为重要的临床验证研究包括SURUSS( theSerum,Urine and Ultrasound Screening Study)[1-2]、FASTER ( the First and Second Trimester Evaluation of Risks Trial)[3]以及BUN (Serum Biochemistry and Fetal Nuchal Translucency Screening)[4].SURUSS研究以寻找为有效、安全和效能比高的唐氏综合征产前筛查模式为目标,在25个筛查中心开展前瞻性研究,终入组47 053例筛查病例,其中包括101例唐氏综合征患儿.
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"11~13周超声扫描颅内透明层诊断胎儿脊柱裂价值"点评
1论文题目及原文摘要Assessment of intracranial translucency ( IT) in the detection of spina bifida at the 11-13-week scanPrenatal diagnosis of open spina bifida is carried out by ultrasound examination in the second trimester of pregnancy.Objective The diagnosis is suspected by the presence of a 'lemon-shaped' head and a 'bananashaped' cerebellum, thought to be consequences of caudal displacement of the hindbrain.The aim of the study was to determine whether in fetuses with spina bifida this displacement of the brain is evident from the first trimester of pregnancy.
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孕中期人绒毛膜促性腺激素水平与产科并发症及病理妊娠关系的Meta分析
为了进一步确定孕中期母血清中高水平人绒毛膜促性腺激素(hCG)与产科并发症的关系,我们对到目前为止发表的关于孕中期高水平人绒毛膜促性腺激素(MshCG)与产科并发症及病理妊娠关系的流行病学文献进行了Meta分析,综合分析hCG与胎儿宫内发育迟缓(IUGR)、早产、子痫前期、妊娠期高血压、小于胎龄儿等产科并发症的关系,并计算合并比值比(OR),以期获得孕中期高水平MshCG与产科并发症及产科并发症关系的可靠依据.