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肥厚型心肌病心房颤动:决定因素、临床进程与处理
心房颤动(房颤)是一个全球性健康问题,东西方患病率相同,反映人群老化,心血管病负担加重.在肥厚型心肌病(HCM)患者中,房颤是常见的持续性心律不齐,常见的并发症之一,对临床病程与预后影响很大.房颤成为HCM治疗的棘手问题,特别年轻患者,需要一致的循证治疗策略.尽管HCM房颤的循证依据不多,近期证据提示,新的治疗方法给某些患者带来了希望.我们需要更加深入的理解房颤的病理生理学,特别是遗传性心脏病患者房颤的病理生理学.我们重点复习HCM房颤的发病与临床预后及处理的进展.
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正电子发射断层成像术在肥厚型心肌病中的应用:发现微血管功能异常所致的心肌低灌注
肥厚型心肌病是常见的遗传性心脏疾病,其在人群中患病率约为2/1000,以表型表达和临床表现差异极大为特点--从完全无症状到猝死、疾病进展和心力衰竭相关并发症等~([1-3]).微血管水平的心肌缺血与疾病表达和临床后果密切相关,是一些致命性并发症,如室性心律失常、猝死、左心室重构和收缩功能障碍的直接原因~([9-16]).
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"11~13周超声扫描颅内透明层诊断胎儿脊柱裂价值"点评
1论文题目及原文摘要Assessment of intracranial translucency ( IT) in the detection of spina bifida at the 11-13-week scanPrenatal diagnosis of open spina bifida is carried out by ultrasound examination in the second trimester of pregnancy.Objective The diagnosis is suspected by the presence of a 'lemon-shaped' head and a 'bananashaped' cerebellum, thought to be consequences of caudal displacement of the hindbrain.The aim of the study was to determine whether in fetuses with spina bifida this displacement of the brain is evident from the first trimester of pregnancy.
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宫颈锥切术对妊娠结局的影响:一项基于人群的队列研究点评
1 原文摘要Objectives To examine the consequences of cervical conisation in terms of adverse outcome in subsequent pregnancies.
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Understanding and Treating Arthrogenic Muscle Inhibition
Quadriceps muscle weakness and dysfunction are common consequences of knee joint injury or effusion.[1-7] Deficits in quadriceps muscle function have been reported following various knee joint pathologies including anterior knee pain, [8-11] anterior cruciate ligament injury, [6,7,12-22] knee joint osteoarthritis,[2,23,24] and meniscus injury.[5,25] Muscle strengthening is regularly the focus of rehabilita-tion regimens,yet,full quadriceps strength is often not re-gained following discharge from formal physical therapy sessions. [19] Additionally some evidence suggests that quadriceps weakness persists long after acute knee joint injury[21] and may be a contributing factor to the onset of osteoarthritis.