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西拉普利对充血型心力衰竭的疗效观察
目的:ACE抑制剂已经广泛地用于治疗严重充血性心力衰竭,但是用于治疗轻、 中度心力衰竭少见报道。本组观察西拉普利对轻、中度心力衰竭的疗效。方法:68例心力衰 竭病人,NYHAⅡ~Ⅲ级,观察治疗前后试验组病人症状、体征和运动试验耐受情况,并同安 慰剂组进行对照。结果:试验组运动耐受程度改善27%,而安慰剂组仅为5%(\%P\%<0.001); 试验 组心力衰竭和NYHA分级也明显提高,两组血清钾、肌酐和尿酸无显著差异。结论:西拉普利明显改善轻、中度心力衰竭的症状,提高运动耐量,而且耐受 良好。
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曲美他嗪对陈旧性心肌梗死康复期运动耐量的影响
Objective To investigate the effect of trimetazidine(TMZ) on exercise capacity of the patients with old myocardial infarction during recovery period. Method 28 patients were administered hitrales, blockers and antipemic agents. 30 patients were administered TMZ 20 mg tid. After 12 weeks ,we compared nitrite expenditures, time to onset of angina after exercise, the time to 1 mm ST segment depression after exercise and rate pressure product. Result Nitrite expenditures per week were significantly reduced than before treatment and comprehensive group(P< 0.001). The rate pressure product of TMZ didn't change significantly(P >0.05). Conclusion TMZ may increase exercise capacity of patients with old myocardial infarction.
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慢性心力衰竭患者Tei指数与心肺运动耐量的相关性研究
日本学者Tei于1995年提出了一种无创综合评价心脏整体收缩和舒张功能的超声检查指标_Tei指数(亦称心肌工作指数),此参数不受心脏几何形态及心脏瓣膜返流等因素的影响[1].本文分析了Tei指数与心肺运动耐量指标(6分钟步行距离及运动峰耗氧量等指数)的相关性,同时进一步探讨了Tei指数对慢性心力衰竭患者心肺运动耐量的预测价值.