To study the therapeutic effect of Chinese herbal medicines (CHM) in treating ascites and to elucidate its mechanism in regulating the lymphatic stomata and promoting the absorption of ascites from the peritoneal cavity. Methods: Using scanning electron microscope (SEM), computerized image processing and quantitative analytic assay, the effect of CHM extract, consisting of Atractylodes macrocephala, Salvia miltiorrhiza, Codonopsis pilosula, Alismatis orientale and Leonurus heterophyllus, was studied. Results: Intraperitoneal injection of nitric oxide (NO) supplier (Sodium nitroprussiate) or CHM administration could cause the average area of lymphatic stomata obviously enlarged (P＜0.05), and the numbers of opening stomata significantly increased (P＜0.01) in normal healthy mice. When L-notroarginine, a NO synthetase suppressor, was injected after CHM administration, the regulating effect of CHM on lymphatic stomata was inverted obviously, i.e. the average area and the density of lymphatic stomata were markedly reduced (P＜0.01). Conclusion: CHM might treat ascites through increasing the endogenous NO concentration to open the lymphatic stomata and in turn to conduct the peritoneal water through lymphatic path.

胃肠外营养(PN)支持治疗急性重症胰腺炎27例报告

目的总结1987年5月～1999年4月我院27例急性重症胰腺炎患者,应用胃肠外营养(PN)支持治疗的经验.方法患者病情大多重危,病程长,平均64天,长179天,并发症多,代谢紊乱和营养不良问题突出.PN支持平均24天,长72天,多数从病程早期开始,覆盖整个消化道功能障碍时期,直到恢复进食.综合治疗十分重要,本组包括:早期1周内手术17例,9、10天手术各1例,术中或(和)术后胰床和腹腔灌洗13例,以及内科治疗措施,后期胰腺脓肿引流及坏死组织清除7例.结果22例治愈(81.5%),死亡5例(18.5%).死因为胰腺脓毒症并发感染性休克3例,衰竭合并肺部感染而发生多脏器功能不全2例,均系后期死亡.结论TPN能满足高代谢状态下营养需求、纠正代谢紊乱,促使消化道及其腺体处于休息状态,是急性重症胰腺炎的基本治疗措施.

Objective. To observe the regulating effects of vascular endothelial growth factor (VEGF) and angiotensinⅡ (ANG II) on the frog's pericardium, lymphatic stomata and angiogenesis so as to reveal their effects and mechanism on the mesothelial permeability, lymphatic stoma regulation and myocardial hypertrophy. Methods. VEGF and ANGⅡ were injected into the frog's peritoneal cavity so as to examine the changes of the pericardial stromata by using transmission electron microscopy, scanning electron microscopy and computerized imaging analysis. Results. Scattered distributed pericardial stomata were found on the parietal pericardium of the frog with a few sinusoid mesothelial cells, whose blood supply was directly from the cardiac chambers flowing into the trabecular spaces of the myocardium (because there are no blood vessels in the myocardium of the frog). The average diameters of the pericardial stomata in VEGF and ANGⅡ groups were 1.50 μ m and 1.79 μ m respectively, which were much larger than those in the control group (0.72 μ m, P< 0.01); the average distribution densities of the stomata were 8.25/0.1 mm2 and 12.80/0.1 mm2 in VEGF and ANGⅡ groups, which were also much higher than those in the control group (3.57/0.1 mm2, P< 0.01); the sinusoid areas in VEGF and ANGⅡ groups were 2442.95 μ m2/0.1 mm2 and 2121.79 μ m2/0.1 mm2, which were larger than that in the control group (995.08 μ m2 /0.1 mm2 , P< 0.01); no angiogenesis was found in the frogs of the experimental groups. Conclusions. VEGF and ANGⅡ could strongly regulate the pericardial stomata by increasing their numbers and openings with larger diameters and higher distribution density. They could also increase the sinusoid areas with the result of the higher permeability of the pericardium, which clearly indicated that VEGF and ANGⅡ could speed up the material transfer of the pericardial cavity and play an important role in preventing myocardial interstitial edema. Yet there was no strong evidence to show the angiogenesis in the myocardium.

小儿急性胃扭转

小儿急性胃扭转比较少见,国内文献报告不多,我院在1982年收治伴有膈肌发育障碍的急性胃扭转2例.