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双相情感障碍认知功能的研究进展
双相情感障碍(bipolar affective disorder,BPD)是1种严重、慢性或终生性疾病.据报道,BPD患病率为1.2%2.4%,约占人群的1.3%,占所有心境障碍的20%~50%.美国BPD患者约为300万,其患病率虽低于抑郁症,但高复发率(高达90%)、高致残率、低诊断率和低治疗率突出.死亡率也相对较高,约25%~50%患者有自杀未遂史,10%~15%自杀身亡,居各类精神障碍之首.当然,BPD所特有的严重后果并不仅如此,认知功能损害也是BPD的重要特征[1].现将近年来关于BPD认知功能损害的文献作一综述.
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外科围术期病人情感障碍调查及对策
手术常被看作是人生中的重大挫折与不幸,是困扰许多外科手术病人的主要应激原,产生比较剧烈的生理与心理的应急反应,这些应急反应如果过于强烈,不仅会给病人造成痛苦,而且会干扰手术与麻醉等医疗活动的顺利实施,从而消极地影响病人的身心康复与治疗效果,甚至造成后遗症[1].
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中国汉人 X染色体上情感障碍易感性基因的遗传学研究及关联分析
Objective In order to detect the Susceptible gene on X chromosome for Han nationality of Chinese who suffer from affective disorder(AD),to explore the association between DXS1114 polymorphism and AD and the feature of genetics.Method We used the technique of the amplified fragment length polymorphism(Amp FLP)to detect the polymorphism distribution of DXS1114 for 40 patients with AD and 40 normal controls.Results We found that there were 4 polymorphism fragments of DXS1114 on the γ -chromosome in AD and normal controls.The result of statistics showed that four polymorphism fragments(117bp.113bp.111bp 109bp)had not significant difference(P>0.05)between patients and normal controls.Conclusion We report that the DXS1114 is not associated with Chinese who suffer from AD.The results indicate that there maybe no a susceptible gene of AD on xq26.1 in our research simples.