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Objective.To identify the A3243G mutation of mitochondrial(mt) DNA in patients with latent autoimmune diabetes mellitus in adults (LADA) of Han nationality in the northeast area of China. Methods.Seventy nine diabetics of Han nationality,whose families have resided in the northeast area of China for more than 3 generations,were divided into 3 groups: Group 1 (22 cases of type 2 diabetes with maternal inheritance history),Group 2 (34 cases of LADA),Group 3 (23 cases of type 1 diabetes in adolescents).The A3243G of mt DNA was detected in these 79 subjects with the method of PCR RFLP. Results.None of the 79 diabetics studied was positively identified for the A3243G mutation of mt DNA. Conclusion.The A3243G mutation of mt DNA might not be related to the onset of LADA in diabetic population of Han nationality in northeast area of China and there might not be close relationship between A3243G mutation of mt DNA and autoimmunity.
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谷氨酸脱羧酶抗体作为IDDM的预测标志
胰岛素依赖型糖尿病(IDDM)是一种自身免疫性疾病,胰岛β细胞呈进行性破坏.成人隐性自身免疫性糖尿病(Latent autoimmune diabetes mellitus in adults,LADA)属IDDM的亚型[1,9].免疫学标志如胰岛细胞抗体(ICA)、胰岛素自身抗体(IAA)和谷氨酸脱羧酶抗体(GAD-Ab)可在新诊断的IDDM患者血中检测到[1~3].
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谷氨酸脱羧酶抗体在成人晚发自身免疫性糖尿病中的诊断意义
Ⅰ型糖尿病(IDDM)是由免疫介导的胰岛β细胞破坏所致的自身免疫性疾病,成人晚发自身免疫性糖尿病(LADA)属IDDM的亚型, 对LADA进行早诊断,采用胰岛素治疗,有利于保护残留的部分胰岛分泌功能, 延缓病情的发展.谷氨酸脱羧酶抗体(GAD-Ab)对这类患者的诊断有一定的意义.