AIM To provide evidence that UBT is the most cost-effective tool for evaluation of H. pylori eradication.METHODS Data on twenty-six consecutive patients at Atlanta VA Hospital who underwent UBT wereretrospectively reviewed. All patients had endoscopic diagnosis of peptic ulcers and biopsy proven H. pyloriinfection. Eight to ten weeks after completion of triple therapy (amoxicillin, biaxin and prilosec), allpatients had C14 UBT (PY test kit, Charlottesville, Virginia). Ten patients had repeated endoscopicexaminations and gastric biopsies. Twelve patients had serology tests for H. pylori.RESULTS UBT was negative in all patients (two patients had indeterminate result on the first time, butshown to be negative on the second UBT). Biopsies from all ten patients who were re-endoscoped werenegative for H. pylori. Serology tests on all the twelve patients were positive. Cure of H. Pylori could notbe determined on the titer change. All patients spent about 30 minutes in nuclear medicine laboratory, theendoscopic patients spent 2 hours to 4 hours in endoscopic laboratory; the cost for a UBT was about 50, thecost for an endoscopy with biopsy was above 200.CONCLUSION The 04 UBT is a rapid, economic and accurate test to monitor H. pylori eradication. Thetest should be considered a gold standard test for evaluating the effectiveness of treatment of H. pyloriinfection, unless patients need repeated endoscopy to rule out gastric cancer.

无创性手段检测HP的意义

目前诊断幽门螺杆菌(Helicobacter pylori,HP)感染的方法有很多,包括依赖胃镜检查的有创性检测方法如快速尿素酶试验(Rapid Urease Test,RUT)、细菌培养、病理组织切片染色等,其他无创性检测方法如血清学检查、13 C呼气试验(13C urea breath test,13 C-UBT)、14 C呼气试验(14C-UBT)、PCR等[1],但每一种检测方法均有其优缺点.本研究旨在探讨无创性检测手段14C-UBT、血清学检查HP-IgG与有创性检测方法RUT、病理组织切片染色对HP感染诊断的敏感性与特异性,从而为临床选用无创性检测手段提供依据.