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许海涛设计是一种坚持
作为国内医院建筑师的"名流"之一,许海涛获得的荣誉很多.他近就获得了我国青年建筑师的高荣誉--中国建筑学会青年建筑师奖.在中国中元国际工程公司医疗建筑设计一所内,一身休闲打扮的许海涛笑着告诉记者:"我开始做医院建筑设计时,也是找不到头绪的,慢慢地才摸索到一点门道,逐渐有了兴趣,才进一步去研究.我觉得,设计是一种坚持."
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细菌持留状态研究进展
目前国内对持留菌的认识多来源于结核分枝杆菌.通常认为结核分枝杆菌在宿主内以非增殖方式存在而造成病程的延缓及导致复发的潜伏状态为细菌的持留状态(persistence),引起这种现象的菌群则为持留菌(persisters).国际上对持留菌的研究并不仅限于结核菌.为此本文就持留菌的发现、研究历程及现阶段研究进展等加以概述,以便对细菌持留现象有更深刻的理解.
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The role of monocyte-lineage cells in human immuno-deficiency virus persistence: mechanisms and progress
Human immunodeficiency virus type 1 (HIV-1) persistence is a major barrier to the successful treatment and eradication of acquired immunodeficiency syndrome (AIDS). In addition to resting CD4+ T cells, a significant long-lived compartment of HIV-1 infection in vivo includes blood monocytes and tissue macrophages. Studying HIV-1 persistence in monocyte-lineage cells is critical because these cells are important HIV-1 target cells in vivo. Monocyte-lineage cells, including monocytes, dendritic cells (DCs) and macrophages, play a significant role in HIV-1 infection and transmission. These cells have been implicated as viral reservoirs that facilitate HIV-1 latency and persistence. A better understanding of HIV-1 interactions with monocyte-lineage cells can potentially aid in the development of new approaches for intervention. This minireview highlights the latest advances in understanding the role of monocyte-lineage cells in HIV-1 persistence and emphasizes new insights into the mechanisms underlying viral persistence.
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病态窦房结综合征并永存左上腔静脉和右上腔静脉缺如安置埋藏式心脏起搏器1例报告
永存左上腔静脉(persistence of the left superior vena cava,PLSVC)是胚胎时期左总主静脉残留所形成的血管畸形,在正常人群的发生率约为0.5%,先天性心血管畸形中的发生率约为2%~5%[1].少数(约10 %)的PLSVC患者可合并静脉右角的退化则伴随右上腔静脉缺如(闭锁),则是较罕见的血管畸形.现报告1例PLSVC并右上腔静脉缺如的病态窦房结综合征(sick sinus syndrome,SSS)患者植入埋藏式心脏起搏器.