首页 > 文献资料
-
Primary osteoporosis, a commonly encountered metabolic bone disease in the postmenopausal women and the aged people, can be classified by modern medicine into postmenopausal osteoporosis (Type I) and senile osteoporosis (Type II). The disease seriously affects health and quality of life of the people as it often cause ostealgia, fracture and the secondary symptoms or diseases. Presently, the pharmacotherapy (including both Chinese herbal drugs and western drugs) remains the first among all other therapeutic methods which are mainly adopted in treatment of the disease at home and abroad. Studies related have been curried out quite early and systematically, and considerable progress has been made, but limit of the pharmacotherapy has also been found. Certain non-drug treatments (such as dietetic therapy, physical exercise, acupuncture and moxibustion, and qigong, especially acupuncture and moxibustion therapy, although with a late start, have been proved effective with satisfactory results. The following is a summary of all the contributions concerned.
-
无力型肾性骨病发病增多:一个应当引起重视的问题
众所周知,几乎所有终末期肾功能衰竭患者都伴随着代谢性骨病.此类骨病,在二十世纪三十年代的个案报告中被称为"肾性佝偻病"(renal rick-ets);而十年后,经过两位中国内分泌专家刘士豪、朱宪彝的系统研究,则将其称为"肾性骨营养不良"(renal osteodystrophy)(Medicine,1943;2:103-161),并一直沿用至今,目前一般简称"肾性骨病"(renal bone disease).
-
成骨不全的分子遗传学研究进展
成骨不全( osteogenesis imperfecta , OI )又称脆骨症( brittle bone disease ),是一种常染色体遗传的先天性疾病,由遗传性中胚层发育障碍造成骨骼脆性增加及胶原蛋白代谢紊乱为特征的结缔组织异常性疾病。 OI病变不仅限于骨骼,其他结缔组织如皮肤、筋膜、肌腱、韧带、动脉、角膜等也常被累及,不同个体间病情严重程度有较大差异。 OI 的发病率为1/20000~1/15000[1],男女发病率相当,为罕见疾病,OI发病的家族性明显。
-
英汉骨质疏松学词汇(续)
Liver-induced osteoporosis,LIOP 肝原性骨质疏松症Male osteoporosis 男性骨质疏松症Malabsorption syndrome 吸收障碍综合症Metabolic bone disease 代谢性骨病
-
肾性骨营养不良(下)
2低转运型骨病(low turnover bone disease)本病以骨形成率异常低下,骨矿化缺损,类骨质厚度正常或增加,成骨细胞表面减少,破骨细胞表面正常或低下,以及软组织钙化发生率增加为特征.ESRD进行透析患者有二种不同的低转运型骨病.即铝相关性骨病和多见的无动力型骨病.
-
骨囊肿植骨后持续被动运动促进骨愈合的疗效观察
Background: Bony cyst is a kind of common benign bone disease, for which, cause is unclear. Multiple bony cyst is rare in clinic. It is supposed metabolic and genetic factors may be involved. People aged 5~ 15 years are commonly affected population (Female: Male 1:2).
-
阿仑膦酸钠对绝经后骨质疏松性骨痛的疗效分析
Background: Osteoporosis is a metabolic bone disease characterized by low bone component and regeneration of the microstructure of bone tissues, osteoporosis occurs in postmenopausal women for decreased estrogen level. Those women with osteoporosis often suffer from bone ache, such as pain at low back, back, knees and heels. In severe cases, there may be crookback or non- violent fracture. Objective: To discuss treatment effect of the Alendronate on 56 postmenopausal women with bone ache caused by osteoporosis. Unit: 210 Hospital of PLA.
-
极低出生体重儿的骨代谢特点及代谢性骨病
随着围产医学的发展,NICU技术水平的发展使得影响极低出生体重儿(very low birth weight,VLBW)存活的严重的并发症(如呼吸窘迫综合征、严重的感染、DIC等)得到了有效控制,VLBW的存活率显著增加.早期肠道外静脉营养的应用,使得VLBW生后早期蛋白质、脂肪的营养得到了保证,生长速度日趋接近宫内发育水平,但早期钙磷等矿物质的摄入量及对骨代谢的影响日益受到关注.代谢性骨病(metabolic bone disease,MBD)是由于体内钙磷代谢紊乱所致的骨矿物质含量的异常,临床表现为类似严重的佝偻病的症状,VLBW由于宫内钙磷储备少、生后摄入不足,所以是MBD的好发人群,随着VLBW的存活率增加,VLBW的MBD呈明显上升趋势.出生体重<1 000 g的早产儿的MBD发生率可达55%,<1 500 g的早产儿23%发生MBD,24%合并骨折[1],故了解VLBW骨代谢的特点,早期监测骨代谢标记物的变化,对于MBD的早期诊断及治疗,保证其骨骼的正常发育是非常重要的.
-
早产儿代谢性骨病4例
早产儿代谢性骨病(metabolic bone disease of prema-turity)又称早产儿骨质减少症(osteopenia of prematurity),是指骨小梁数量减少,骨皮质变薄等所致的机体骨组织含量减少[1],严重者可出现佝偻病样表现,甚至骨折.
-
前列腺癌骨转移治疗的新进展
65%~75%的高分级前列腺癌伴骨转移(metastatic bone disease,MBD),5年存活率仅为25%,中位生存期近40个月[1].去势治疗(androgen-deprivation therapy,ADT)前列腺癌18~20个月后,可进展为去势抵抗性前列腺癌(castration-resistant prostate cancer,CRPC)[2].评估显示近30%的CRPC患者伴MBD.其中22%的患者可单发或多发病理性骨折;7%的患者发生脊髓压迫;3%~4%的患者发生偏瘫或局部麻痹[3].晚期肿瘤所致MBD,有顽固性骨痛、病理性骨折、脊髓压缩和生存率下降的风险.这些临床症状给患者带来了极大的痛苦.本文就前列腺癌MBD的机制以及新的治疗方案做一综述.
-
甲状旁腺激素的不同检测方法及其在肾性骨病诊断中的价值
甲状旁腺激素(PTH)作为一种尿毒症毒素,日益引起人们关注.它可以引起多种器官损伤,如肾性骨病、心脏肥大、软组织钙化等.一直以来,PTH检测是临床上诊断、监测肾性骨病的主要手段.但近来有研究报道,维持性血透患者的PTH值不能正确判断骨转运状态,甚至iPTH>500pg/ml的患者骨活检也有显示低转运性骨病的可能.那么,PTH水平是否能够反映骨病状态呢?还是PTH检测方法不能反映真实的PTH值呢?为此我们回顾一下目前的进展.
-
负荷剂量邦罗力在肺癌骨转移治疗中的应用
转移性骨病(Metastatic Bone Disease,MBD)是肺癌患者常见的严重并发症,影响患者的生活质量,且预后较差.依班膦酸盐(邦罗力)是第三代双膦酸盐化合物,是临床上强的破骨细胞活性抑制剂[1].