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AIM To investigate the effect of BCG vaccine and dipyridamole in treating hepatitis B due to their anti-virus effects.METHODS Among 602 patients with positive HBeAg, 512 were allocated to the treatment group and 90patients to the control group. There was no significant difference in disease and age between the two groups.All the patients in the treatment group with no abnormal findings by chest X-ray fluoroscopy, whose localskin scleromata diameters were less than 7 mm after the 1:2000 OT test, were given BCG vaccine 0.1 mlintracutaneously at the deltoid once a month, and simultaneously took dipyridamole 50 mg twice a day forfour to eight months. The hepatic function, B-mode ultrasound and the five markers of hepatitis B wereroutinely examined before each injection. The results at one month after the last injection in the treatmentgroup were compared with those of the control group.RESULTS The recovery rates of hepatic functions and the rates of improvement of the symptoms and signsin the treatment group were better than those in the control group. The negative transformation rates ofHBeAg and the positive transformation rates of HBeAb were 60.3% and 31.6% in the treatment group vs.13.3% and 13.0% in the control group (P<0.01, Test x2, x2=26.82, 6.81). The negative transformationrates of HBsAg and the positive transformation rates of HBsAb were 5.5% and 8.2% in the treatment groupvs. 5.6% and 9.9% in the control group (P>0.05. Test x2, x2=1.11, 0.22).CONCLUSION The application of BCG vaccine in combination with dipyridamole increased the negativetransformation rate of HBeAg and the positive transformation rate of HBeAb, improved the clinicalsymptoms, signs and hepatic function of the patients. These two drugs had significant anti-HBV effect andshowed good efficacy in the treatment of HBV infection.
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膀胱癌术后卡介苗膀胱灌注病人的护理
膀胱癌是泌尿系统常见的恶性肿瘤,其中浅表性膀胱癌占80%,经尿道膀胱肿瘤电切术(TUR-Bt)是目前治疗浅表性膀胱肿瘤常用的手术方式,但术后约有40%~85%在6个月至1 a内复发,膀胱内灌注卡介苗(BCG)是防止或延缓肿瘤复发的有效方法.
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卡介苗膀胱灌注并发症原因分析及护理干预
卡介苗(BCG)膀胱内灌注作为治疗和预防膀胱肿瘤复发的方法已被世界学者公认及推广[1].BCG是一种减活的结核杆菌,被灌入膀胱后可引起炎症反应并释放细胞因子,通过免疫反应破坏肿瘤细胞并防止肿瘤复发.