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To explore the effect of Buyang Huanwu Decoction (BHD) on platelet activating factor (PAF) content in arterial blood pre- and post-arterial thrombosis in rats, male Wistar rats were randomly divided into 3 groups, the medicine group treated with BHD, the control group with dexamethasone liquid, and the blank group with distilled water. Oral administration was given for 14 consecutive days, once daily. Model of arterial thrombosis was established in the animals 2 hours after final medication, the blood content of PAF, dry weight (DW) and occlusion time (OT) of thrombus, and dry weight of thrombus/body weight (TW/BW) ratio were observed. Results indicated that BHD could markedly lower the arterial blood content of PAF after thrombosis, increase the OT of thrombus, reduce the dry weight of thrombus and the TW/BW ratio (P<0.05). It is suggested that BHD can inhibit the pathologic PAF metabolism and formation and development of arterial thrombus.
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冠心病患者血小板活化因子(CD62p、CD63)表达的临床意义
血小板功能和活性的改变是冠心病(CHD)血栓形成的主要环节[1].血小板活性增强不仅促进动脉粥样硬化的发生,更是导致冠状动脉血栓和急性心肌梗死的重要原因.我们应用美国Becman Culter公司的流式细胞仪(FCM)及单克隆抗体标记法技术检测血小板活化因子CD62p、CD63,旨在探讨CHD患者血小板活化因子表达的临床意义.