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Application of biomarkers in sentinel lymph node biopsy for the management of breast cancer
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Clinical challenges in the ataxias
Ataxias are rare diseases and the etiologic heterogeneity make individual entities even rarer. There are still substantial numbers of patients who are still poorly understood. Available assessment techniques still point to large numbers of patients needed for clinical trials and the need for cooperative efforts, better assessment tools and novel trial designs. Better understanding of neural circuitry abnormalities may lead to more effective symptomatic therapy. Opportunities exist for targeting at risk individuals for effective therapies but how this can be done is not clear. Preventive strategies may become feasible in many ataxias.
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Cell Signaling in Viral and Oncogenic Pathogenesis and Its Implications in Disease Diagnosis and Prognosis
Both viral diseases and cancer account for a large proportion of serious health problems.Viral infection and cancer are biologically and medically correlated and in many ways share common cellular pathways that lead to disease development or progression.Better understanding how these signaling events are specifically activated by different pathogenic stimuli and how they activate different downstream transcriptions in response to these stimuli at high specificity and efficiency will provide a new molecular basis for the development of novel disease biomarkers and therapeutic or preventive targets against both classes of diseases.Research in our laboratory has been prompted to investigate the regulation and modes of action of these pathways,with a more intensive focus on the NF-кB signaling,in the settings of severe or oncogenic viral infection as well as cancer development.It is hoped that our research will lead to eventual clinical application of biomarkers derived from these signaling pathways.