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缺氧预适应过程中的小鼠脑一氧化氮下调
Downregulation of nitric oxide in the brain of mice during their hypoxic preconditioning.J Appl Physiol 91:1193～1198,2001.An animal model of hypoxic preconditioning was produced in mice by repeated exposure to autohypoxic condition.The animals' tolerance times to hypoxia were 1.7,1.8,2.1 and 2.3 times longer in runs 2,3,4 and 5,respectively,than that in run 1,and their oxygen consumption and heart and respiration rates were progressively and significantly slowed down during the repetitive exposure to hypoxia.L-arginine concentration,nitric oxide (NO) synthase-positive cells,NO synthase activity,and NO content in the whole brain and the subregions telencephalon,diencephalons,and brain stem were significantly increased during the first exposure and were,instead of continuing to increase,significantly decreased in run 4 after the second and third exposure.Tolerance times under the hypoxic condition were significantly shortened and prolonged when preadministration of L-arginine and its analog,respectively,was made.These results indicate that NO in the brain is downregulated under condition of hypoxic preconditioning and negatively involved in increased tolerance to hypoxia.
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过敏性休克--一种没有抑制氧耗的分布性休克
背景:麻醉中发生过敏性休克的病理生理尚未完全阐明.它被认为是一种具有分布性的类似于感染性休克(无氧代谢,高组织氧压[PtiO2])的一种休克形式.过敏性反应中组织氧压的情况及其结果至今尚未知晓.
