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To elucidate the molecular mechanism on anti-arrhythmic function of Dingxin Recipe (DXR). Methods: Cardiac myocytes isolated by trypsin method were cultured and labeled with various fluorescence stains. DXR contained serum induced changes of cellular calcium concentration 〔Ca2+〕i, cell membrane potential (MP) and mitochondria membrane potential (MMP) were determined with laser confocal microscopy. Results: Hypoxia caused increase of 〔Ca2+〕i and MMP, and decrease of MP, while DXR contained serum lowered the 〔Ca2+〕i in normal or hypoxic myocytes, improved hypoxia induced MP reduction and maintain MMP at baseline level under hypoxia circumstances. Conclusion: Through inhibiting the hypoxia caused 〔Ca2+〕i and MMP elevation and MP lowering, DXR displays its action in protecting myocardial cells to prevent and treat arrhythmia.
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关键词: myocardial cells
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中药对心肌细胞损伤保护作用的研究进展
随着生活模式现代化与社会老龄化进程的加快,心血管疾病的发病率在全球范围内逐年增加,已成为严重危害人类健康的慢性疾病.目前,中医中药在心血管疾病的预防及治疗中已占据重要的地位,通过一系列实验和临床研究,逐步深入了解中药对心肌细胞的作用机制.本文就中药对培养心肌细胞损伤的保护作用机制作一综述.