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Under the auditory evoked brain stem potential (ABP) examination, the latent period of V wave and the intermittent periods of III-V peak and I-V peak were significantly shortened in Parkinson's disease patients of the treatment group (N=29) after acupuncture treatment. The difference of cumulative scores in Webster's scale was also decreased in correlation analysis. The increase of dopamine in the brain and the excitability of the dopamine neurons may contribute to the therapeutic effects, in TCM terms, of subduing the pathogenic wind and tranquilizing the mind.
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缺氧预适应过程中的小鼠脑一氧化氮下调
Downregulation of nitric oxide in the brain of mice during their hypoxic preconditioning.J Appl Physiol 91:1193~1198,2001.An animal model of hypoxic preconditioning was produced in mice by repeated exposure to autohypoxic condition.The animals' tolerance times to hypoxia were 1.7,1.8,2.1 and 2.3 times longer in runs 2,3,4 and 5,respectively,than that in run 1,and their oxygen consumption and heart and respiration rates were progressively and significantly slowed down during the repetitive exposure to hypoxia.L-arginine concentration,nitric oxide (NO) synthase-positive cells,NO synthase activity,and NO content in the whole brain and the subregions telencephalon,diencephalons,and brain stem were significantly increased during the first exposure and were,instead of continuing to increase,significantly decreased in run 4 after the second and third exposure.Tolerance times under the hypoxic condition were significantly shortened and prolonged when preadministration of L-arginine and its analog,respectively,was made.These results indicate that NO in the brain is downregulated under condition of hypoxic preconditioning and negatively involved in increased tolerance to hypoxia.
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急性自发性脑干出血并发中枢性呼吸衰竭的急救护理
急性自发性脑十出血起病急、病情重、进展快、病死率高,是脑血管疾病中预后差、病死率高的疾病,而出血部位累及呼吸中枢,导致中枢性呼吸衰竭,则预后更差,病死率更高,积极治疗呼吸衰竭是提高脑干出血存活率的关键[1].我院于2001年1月-2005年12月共收治了37例脑干出血病人,其中并发中椒性呼吸衰竭13例.现将护理体会报告如下.
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中青年脑血管病后阗痫178例临床研究
1 Subject and method 1.1 Clinical data 178 middle aged patients suffered from epilepsy following cerebrovascular diseases were recriuited including 104 males,74 females aged from 20~ 59 years(mean age:48 years old).Among them,24 cases aged from 20~ 29 years,40 aged from 30~ 39 years,54 aged from 40~ 49 years,60 aged from 50~ 59 years. CT and MRI findings showed ischemic damage in 96 cases, hemorrhage damage in 82 cases.Lesions were located in frontal lobe in 42 cases,14 lesions were located in temporal lobe,8 in occipital lobe,10 in frontoparietal lobe,8 in frontotemporal lobe,4 in parietotemporal lobe,26 in internal capsule of basal nodule,6 in thalamus,4 in brain stem,30 in subarachnoid cavity.12 patients exhibited multiple lesions.
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脑干诱发电位对椎基底动脉系短暂性缺血发作的诊断价值
BACKGROUND:Brain stem auditory evoked potential(BAEP) can objectively reflex nerve conduction function of auricular conduction pathway and indirectively reflex functional status of the brain stem.
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pSVPoMcat微基因修饰雪旺细胞脊髓内移植对操作脊髓再生的影响
Objective In order to observe the role of genetically modified Schwann cell (SC) with pSVPoMcat in the regeneration of injured spinal cord.Method The cells were implanted into the spinal cord.Ninety SD rats were used to establish a model of hemi- transection of spinal cord at the level of T8,and were divided into three groups,randomly, that is,pSVPoMcat modified SC implantation(Group A), SC implantation(Group B),and without cell implantation as control(Group C).After three months the presence of axonal regeneration of the injured spinal cord was examined by means of horseradish peroxidase(HRP)retrograde labeling technique and stereography.Result The results indicated that HRP labeled cells in Group A and B could be found in the superior region of injured spinal cord and the brain stem such as the red nuclei and oculomotor nuclei. The density of ventral horn neurons of the spinal cord and the number of myelinated axons in 100 μ m of the white matter was A >B >C group.Conclusion In brief,the pSVPoMcat modified SC intraspinal implantation could promote regeneration of the injured spinal cord.
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21例原发性脑干出血的 CT诊断
原发性脑干出血起病急骤、出血量大,病情危重.少量出血时临床症状不典型,CT检查能获得正确诊断及早治疗,可使死亡率大大降低.
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脑干内脓肿破裂一例报道
脑干内脓肿十分罕见,本文报道一例非典型桥脑脓肿破裂造成弥漫性脑膜炎和室管膜炎病例,以供借鉴.
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儿童后颅凹室管膜瘤(附243例分析)
室管膜瘤是儿童期比较常见的颅内肿瘤,多数位于后颅凹.现将我院1958~1981年收治,并经病理证实的儿童后颅凹室管膜瘤(包括室管膜母细胞瘤)243例的诊治经验介绍如下.临床资料一、性别及年龄本组男性145例(59.7%),女性98例.年龄分布:4个月~3岁32例,4~7岁76例,8~12岁99例,13~15岁36例.年龄:小者为4个月,平均就诊年龄为8.1岁.
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AIM: To study the expression of c-fos mRNA in brain following moderate lateral fluid percussion brain injury in rats, and to observe the temporal patterns of its expression following percussion. METHODS: Male Sprague-Dawley rats were divided into normal control, sham operation control and injury group. The rats of injury group subjected to moderate lateral fluid percussion injury (0.2 mPa). The injury groups were then subdivided into 5 min, 15 min, 30 min, 1h, 2h groups according to the time elapsed after injury. The expression of c-fos mRNA was studied with reverse transcription polymerase chain reaction (RT-PCR) semi-quantitatively.RESULTS: At 5 min after percussion, the induction of c-fos mRNA was increased, and remained elevated up to 2 h after brain injury.CONCLUSION: The induction and expression of the c-fos mRNA in cortex and brain stem after fluid percussion brain injury were increased rapidly.
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AIM: To study the expression of c-jun in brain stem following moderate lateral fluid percussion brain injury in rats, and to observe the temporal patterns of its expressions following percussion.METHODS: Male Sprague-Dawley rats were divided into normal control, sham operation control and injury groups. The rats of injury group subjected to moderate lateral fluid percussion injury (0.2 mPa), and then were subdivided into 5 min, 15 min, 30 min, 1 h, 2 h, 4 h, 8 h and 12 h groups according to the time elapsed after injury. The expression of c-jun was studied by immunohistochemistry and in situ hybridization. RESULTS: After percussion for 15 min, Jun positive neurons increased in brain stem progressively, and peaked at 12h. At 5min after percussion, the induction of c-jun mRNA was increased, and remained elevated up to 1h-2h after brain injury. CONCLUSION: The induction and expression of the c-jun in brain stem after fluid percussion brain injury were increased rapidly and lasted for a long time.
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