酯苷胶囊对小鼠移植瘤的抑制作用

目的:探讨酯苷胶囊对小鼠移植性肿瘤的抑制作用.方法:采用小鼠移植性肿瘤模型,以5-FU为阳性对照组,观测2、4、8mg? kg-1酯苷胶囊对小鼠H22、S180肉瘤和HCA肝癌模型动物的抗肿瘤作用.结果:酯苷胶囊对H22、S180和HCA移植瘤的抑制率分别为36.8％～65.3％,19.0％～41.4％,46.8％～52.3％.结论:酯苷胶囊具有较强的抗肿瘤作用,显著延长荷瘤小鼠的生命.

肝细胞腺瘤1例报道及文献复习

肝细胞腺瘤(hepatocellular adenoma,HCA)是一种十分少见的肝脏良性肿瘤,患者常无任何临床症状,但肿瘤有破裂出血及癌变的可能,临床上与原发性肝癌鉴别困难.通过对本院收治的1例HCA患者的临床资料进行总结,并结合文献对此类疾病的临床病理特征进行分析,现报道如下.

安迪粉针剂抗肿瘤作用的实验研究

目的探讨安迪粉针剂(简称安迪)对小鼠移植性肿瘤的抑制作用,以及对其免疫功能的影响.方法采用小鼠移植性肿瘤即艾氏腹水癌(ECA)、肉瘤180(S180)、肝癌(HCA)、Lewis肺癌模型,以5-FU为阳性对照组,观察25,12,6 mg*kg-1安迪的抗肿瘤作用,并采用小鼠溶血素实验和小鼠迟发性变态反应实验观察安迪对荷瘤小鼠免疫功能的影响.结果不同浓度安迪对体外ECA肿瘤细胞的蓝染率分别为100%,96%,89%,65%和49%(P＜0.01);安迪对S180、HCA和Lewis移植瘤的抑制率分别达42.1%～54.8%,38.2%～53.5%和42.1%～55.3%(P＜0.01);对小鼠腹水型HCA的生命延长率为110.4%～136.1%(P＜0.01);与阳性对照组比较,安迪对荷瘤小鼠免疫功能无抑制作用.结论安迪具有较强的抗肿瘤作用,且对荷瘤小鼠免疫功能无影响.

A simple and rapid gas chromatography/mass spectrometry (GC/MS) analysis method was developed for the determination of fat-soluble parts of sinapis semina. Four major compounds were chosen as marker compounds to evaluate the method. Various extraction techniques were evaluated and the greatest efficiency was observed with sonication extraction using diethyl ether. The method was valuated as follows:acceptable apparatus suitability was obtained by testing the resolutions, tailing factors and theoretical plate number of the marker compounds; the precision and reproducibility, expressed as relative standard deviation (RSD), fell within the prescribed limits. Eight samples of sinapis semina collected from markets in Xi’an were monitored by using the method. The fingerprints of those samples were analyzed by hierarchical cluster analysis (HCA) similarity analysis. The result indicated that the combination of fingerprint and HCA could be used to analyze sinapis semina from different habitats.