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溃疡性结肠炎病人并发广泛动静脉血栓栓塞
前言据报道,有25%~36%的原发性炎性肠病(IBD)患者有肠道外表现,即全身表现:骶髂关节炎(14%),外周性关节炎(10.7%),眼损害(8%)、粘膜皮肤受损(2.7%)及血管并发症的表现(2%),其中,后三者较少见.外周静脉血栓和肺动脉栓塞占了血管并发症的60%以上.肠系膜静脉、肝门静脉和大脑静脉发生栓塞较少见,动脉血栓栓塞更不常见.本文所涉及的案例是一个年轻的溃疡性结肠炎女性患者同时并发外周静脉、大脑静脉系统及外周动脉系统栓塞的报道.
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干细胞治疗顽固性溃疡性结肠炎探讨
顽固性溃疡性结肠炎(ulcerative colitis,UC)指诱导或维持缓解治疗失败,通常为皮质激素抵抗或依赖的病例(<胃肠病学>,2007).皮质激素抵抗是指泼尼松龙足量(0.75mg·kg-1·d-1)应用4周不缓解者.皮质激素依赖是指泼尼松龙减量至10 mg/d即无法控制发作(用药3月不能减至10 mg/d以下)或停药后3月复发者.对这些激素依赖或者抵抗的顽固性溃疡性结肠炎,如何寻找有效的治疗方法成为临床研究的难点和重点.近年来,干细胞的研究为溃疡性结肠炎治疗带来新希望.
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溃疡性结肠炎X线与内窥镜检查的对照研究(附15例分析)
溃疡性结肠炎是一种原因不明的慢性结肠溃疡性炎症[1].现就本院1998-02~1999-12经临床及病理证实并且X线及内窥镜检查资料完整的15例结果进行对比分析,以提高结肠气钡双重造影对溃疡性结肠炎诊断价值的认识.
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Background: There are reports on mesalamine-induced bloody diarrhea mimicking ulcerative colitis (UC) relapse, mostly in adults.
Methods: Herein we present a case of a child with UC who developed relapse of hemorrhagic colitis related to mesalamine.
Results: A 10-year-old girl developed severe symptoms mimicking UC relapse 3 weeks after introduction of mesalamine therapy. After mesalamine was withdrawn, her symptoms improved, but deteriorated again during the challenge of mesalamine despite concomitant use of corticosteroids.
Conclusion: This is the fi rst case report on such a young child during the concomitant use of corticosteroids. -
Current treatment for inflammatory bowel disease
Introduction Idiopathic inflammatory bowel disease consists of Crohn's disease (CD) and ulcerative colitis (UC). CD can affect any part of the gastrointestinal tract, from the mouth to the anus, and is also known as regional enteritis, terminal ileitis, or granulomatous……