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microRNA 与骨肉瘤的研究进展
骨肉瘤是好发于儿童和青少年的骨恶性肿瘤，它的第二个好发高峰是在70～80岁的老年人[1]。在美国，每年新发的骨肉瘤患者约为900例[2]。美国癌症中心的数据显示，骨肉瘤患者的5年生存率约为53.9%[3]。新辅助化疗的应用使得骨肉瘤的5年生存率有了明显提高，但是仍有一部分患者对化疗不敏感，同时肿瘤的复发和转移一直是治疗的难题。虽然骨肉瘤相对于其它肿瘤而言较为少见，但是由于它的高致死率和致残率，有关骨肉瘤的基础研究和临床治疗策略一直是医学界的研究热点。之前的研究已经发现骨肉瘤细胞中存在多种遗传学改变，包括染色体结构的异常、缺失等以及肿瘤抑制基因的突变。DNA 的甲基化等表观遗传学的改变也会导致骨肉瘤的发生。尽管有关骨肉瘤的基础研究层出不穷，但是有关microRNAs ( miRNAs )在骨肉瘤的发生和发展过程中所起的作用仍不是十分明确[4]。
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血管紧张素转换酶基因多态性与高血压病早期腔隙性脑梗死的关系
AIM:To investigate the relationships between angiotensin converting enzyme gene polymorphism and lacunar infarction in patients with essential hypertension.METHODS:Polymerase chain reaction(PCR) was used to determine the genotypes for an insertion/deletion polymorphism of 287 pb fragment of ACE gene in 50 healthy persons,50 patients with simple essential hypertension and 30 patients with essential hypertension and lacunar infarction.RESULTS:There was no significant difference of genotype and allele between healthy persons and patients with simple essential hypertension;but there was significant difference of D allele and DD genotype of ACE gene between esential hypertensive patients with lacunar infarction and patients with simple essential hypertension and healthy persons.CONCLUSION:There is a significant relation between ACE gene polymorphism and essential hypertensive patients with lacunar infarction.
