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骨生化指标在骨肿瘤中的临床应用进展
骨肿瘤是起源于间充质细胞，发生于骨组织及其附属结构的一类良、恶性肿瘤的总称，骨肿瘤的发病率女性约为1.060/10万，男性约为1.112/10万，虽属少见的肿瘤类型，但对人体的危害大，特别是恶性肿瘤，目前疗效虽然提高，但仍不令人满意，发病趋势呈年轻，在骨科领域中占有重要地位[1]。正常的骨代谢是骨生成和骨吸收的动态平衡，这种平衡主要有骨组织中成骨细胞或破骨细胞维持，当这种平衡被打破时就会表现出各种骨疾病。骨生成和骨吸收异常伴随的生化指标及导致骨生成和骨吸收变化的相关因素均可作为骨肿瘤的生物标记。随着分子生物学技术的发展，有望通过检测骨肿瘤患者体内的生化指标变化达到早期诊断和治疗的目的。现在就骨组织生化指标在骨肿瘤患者诊治中的研究作一综述，以探讨他们的临床应用价值。
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异体脱钙骨基质骨粒复合骨水泥骨缺损修复材料结构特征及生物力学性能
AIM: To analyze constructive and biomechanical properties of different quality ratio material impregnated decalcified bone matrix (DBM) with bone cement (BC) . METHODS: The DBM particles and the materials impregnated 0 rmg/g, 300 mg/g and 400 mg/g maas ratio DBM particles with BC were made according to the methods of Urist et al. The compound material constructions were observed by scanning electron microscope and the biomechanical properties were measured by Instron mechanics testing-machine. RESULTS: The DBM particles with irregular gaps existing within interspace were connected with BC by the multipoint mode in the compound material. The ultimate compressive strength were 0 mg/g DBM in (59.3 ±2.2) MPa, 300 mg/g in (27.1 ±1.8) MPa, 400 mg/g in (19.3±1.6) MPa. The ultimate bending strength were 0 mg/g in (54.3±3.7) MPa, 300 mg/g in (18.5±1.1) MPa, 400 mg/g in (13.3±1.4) MPa. CONCLUSION: The materials of DBM impregnated with BC had perfect plastic property with much more irregular gaps existing within interspace. The materials could provide abundant biomechanical support.
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烧伤后上肢残留功能障碍修复2例报告
Materials Case 1:Female,16 years old,peasant was admitted to our hospital due to upper limbs dysfunction 1 year after left armpit burn.Physical examination showed good status,contractured hard scar (14 cm× 18 cm) with irregular surface in left armpit.Movement range of shoulder joint is 10 degrees under forward flexion position,5 degrees under backward extension position,5 degrees in outward extension.Preoperative X ray showed no abnormal changes in bone matrix of left shoulder joint.Scar was excised under pamplegia during selective date.Skin defect was repaired by scapular flap (about 15 cm× 10 cm)with vessel pedicle.Case 2:Male,20 years old,peasant.was admitted due to upper limbs dysfunction 1 years after right armpit burn.Physical examination showed good status,contractured scar(16 cm× 9 cm) in right armpit.Movement range of shoulder joint is 10 degrees under forward flexion position,10 degrees under backward extension position,5 degrees in outward extension.Preoperative X ray showed no abnormal changes in bone matrix of right shoulder joint.Scar was excised under pamplegia during selective date.Skin defect was repaired by scapular flap (about 17 cm× 10 cm)with vessel pedicle.
