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上臂平滑肌肉瘤1例
患者,男,38岁,因“发现右上臂肿块5 d”于2014年4月22日来我院就诊。5 d 前患者无意中发现右上臂有一肿块,肿块无疼痛,肢体无麻木不适。无肿瘤家族史及外伤史。查体：生命体征平稳,右上臂内后侧可触及一8 cm ×8 cm 大小的肿块,质韧,边界清,活动度可,肿块无压痛,Tinel 征阴性,肿块表明未见明显红肿及静脉曲张,局部皮温无增高(见图1)。肢端血供、感觉、活动良好,余肢体无殊。 B 超提示：右上臂肌层内不均质低回声团。 MRI 报告：右上臂肌间隙占位,恶性肿瘤首先考虑(见图2)。肿瘤指标：鳞状细胞癌相关抗原3．1μg/ L,甲胎蛋白10．4μg/ L。
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PRUNE2 plays an important role in regulating tumor celldifferentiation, proliferation, and invasiveness in neuroblastoma. Our previous study revealed that PRUNE2/OBSCN two-gene relative expression classifer accurately differentiated leiomyosarcoma from gastrointestinal stromal tumor. However, the association between PRUNE2 expression and prognosis in leiomyosarcoma is poorly understood. In this study, we evaluated the prognostic role of PRUNE2 in leiomyosarcoma. PRUNE2 expression was detected using immunohistochemistry in 30 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from MD Anderson Cancer Center, and high expression was detected in 36.7%(11/30) of the samples. To validate these results, immunohistochemistry was performed on another cohort of 45 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from Tianjin Medical University Cancer Institute & Hospital, and high PRUNE2 protein expression was detected in 37.8%(17/45) of the samples. Moreover, elevated PRUNE2 expression was significantly associated with tumor size (P = 0.03) and hemorrhage/cyst (P = 0.014), and was an independent favorable prognostic factor for overal survival in leiomyosarcoma patients from Tianjin Medical University Cancer Institute & Hospital (P < 0.05). These data suggest that increased PRUNE2 protein expression may serve as a favorable prognostic marker in human leiomyosarcoma.
