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前额叶皮层的5-HT谷氨酸:一个新的抗精神病药的靶点
Activation of neocortical 5 hydroxytryptamine 2A (5-HT2A) re ceptors is thought to mediate the profoud psychominetic effects of hallucinogeni c drugs such as lysergic acid diethylamide(LSD).Coversely, blockade of neocortic al 5-HT2A receptor may be related to the thymoleptic effects of newly rele ased antidepressant especially atypical antipsychotic drugs. Electrophsiological experiments using in vitro rat slices of the medial prefrontal cortex has f ound that activation of 5-HT2A receptors results in glutamate release fr om thalamocortical terminals.In addition to activation of 5-HT2A receptors , metabotropic glutamate (mGluR),and neuropeptide (μ-opioid) receptors suppress this release of glutamate that is induced by 5-HT2A receptor activation. Recent clinical reports have found clear structural change in the prefrontal cor tex of depressed patients. Furthermore, a number of post-mortem studies of suici des from different laboratories have found an increased number of 5-HT2A b inding sites in certain regions of the prefrontal cortex. Thus,understanding the effects of 5-HT2A receptor activation in prefrontal cortex is likely to b e relevant for the development of antidepressant drugs.
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口服抗精神病药物引起神经阻滞剂恶性综合征1例
神经阻滞剂恶性综合征(neuroleptic malignant syndrome, NMS)又名抗精神病药物恶性综合征是一由抗精神病药物治疗时所产生的危及生命的严重并发症，主要临床表现为高热、意识障碍、肌强直和自主神经功能紊乱以及肌酸磷酸激酶(CPK)升高［１］。作者曾遇到1例，介绍如下。
关键词： 地西泮 奋乃静 安定药 强 神经阻滞剂恶性综合征 -
抗精神病药物致静脉血栓形成12例分析
抗精神病药物引起静脉血栓形成国内报道尚少,现就本院发现的12例作一临床分析.
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陈夏六君子丸治疗抗精神病药流涎副作用56例疗效观察
目的:观察陈夏六君子丸治疗抗精神病药流涎副作用的疗效.方法:将110例因使用抗精神病药致流涎的患者随机分为2组,治疗组56例,口服陈夏六君子丸;对照组54例,使用安坦或非那根治疗.用记分法评价疗效.结果:治疗组痊愈38例,显效11例,好转6例,无效1例,总有效率98.21%;对照组痊愈34例,显效12例,好转3例,无效5例,总有效率90.74%;2组总有效率比较,差异无显著性意义(χ2=2.98,P＞0.05).结论:陈夏六君子丸对抗精神病药所致流涎疗效确切.
