Objective: To explore the diagnostic and therapeutic approach of integrated traditional Chinese and western medicine (TCM-WM) on infectious multiple organs dysfunction syndrome/multiple system and organ failure (MODS/MSOF) for elevating the successful rate of rescuing the patients. Methods: Diagnosis with western medicine and Syndrome Differentiation of TCM in 225 in-patients of acute infectious disease complicated with MODS/MSOF were conducted, and TCM treatment, based on western medical comprehensive treatment, was given to observe the effect and explore the mechanism of the TCM-WM therapy. Results: Up to the end of 1998, 161 cases of the 225 cases were successfully cured and 64 died, the mortality being 28.4%. Among them, 58 out of 140 cases of MSOF died, the mortality was accounted for 41.4%. In 106 cases conformed to the diagnostic criteria of MSOF proposed by Professor Knaus WA, USA, 52 cases were cured successfully and 54 died, the mortality being 50.94%. Conclusion:TCM-WM treatment could elevate the therapeutic effect in treating MODS, the mechanism might be through improving the hemodynamic and hemorrheologic condition of patients to relieve nail-fold microcirculation disorder; influencing the levels of cytokine and inflammatory mediator, so as to alleviate the systemic inflammatory reaction, it might also abate the inhibited condition of gastro-intestinal motility, alleviate the intestinal flora imbalance, prevent intestinal bacteria and endotoxin malposition, and protect cells from peroxidation.

结肠粘膜表面保护系统与肠道菌群

人类的肠道菌群极为复杂,在胃肠道的不同部位有不同的菌群聚集.食物中正常含有大量的细菌,但大部分的细菌对于粘膜表面没有粘附能力.在过去的20年中,大量的研究集中在细菌易位以及易位过程中细菌的作用[1～4],而对于正常菌群的保护作用、粘膜的功能以及局部粘膜的保护系统作为一个整体研究得比较少.越来越多的证据表明,功能完好的正常菌群以及正常的粘膜保护作用不仅可以防止细菌感染,而且对于炎症、溃疡、变态反应以及肿瘤性疾病具有重要的作用.