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胰岛素抵抗与血管内皮细胞功能异常--高游离脂肪酸血症扮演了主要角色?
代谢综合征患者缺血性心血管疾病患病危险性显著高于普通人群,其机理与多种因素有关.血管内皮细胞功能异常是代谢综合征的组成成分之一,是动脉粥样硬化启动及恶化的重要因素,而高游离脂肪酸(FFA)血症又是存在于代谢综合征患者中的一个普遍现象.本文将就近年来在胰岛素抵抗状态下高FFA血症对血管内皮细胞功能影响的研究进展作一简要综述.
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严重烧伤后早期大鼠肾脏细胞粘附分子1和白介素6的表达与肾功能损害的相关性研究
Objective To clarify the mechanism and provide the basis for prevention and treatment of the early injuries of kidney after severe burn in rats.We observed the expression of intercellular adhesion molecule 1 and interleukin 6 and the early pathological changes in different time.Method Early pathological changes in the kidney were observed by LM and EM.The expression of ICAM 1 were observed by immunohistochemistry,in situ hybridization.The expression of IL 6 was also observed.Result From 5 min to 72 h after burn,the early changes in the kidney included edema,hemorrhage, and congestion,injury of capillary epithelium cells.2ICAM 1 and IL 6 were higher in the kidney 30 min after burn,and from 2 h to 24 h,they were strongest positive,but on 72 h,they were negative.Conclusion ICAM-1 and IL 6 may play important roles in mechanisms of kidney injury,and the major target cells may be the endothelium cells.
关键词: endothelium cell kidney ICAM-1 burn