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Spectrophotometric determination of tranexamic acid using vanillin
A new spectrophotometric method has been examined for the determination of the tranexamic acid (TA)by derivatization with vanillin(VAN).The molar absorptivity of TA was calculated 25 160 L·mol-1·cm-1at λ max 354 nm and obeyed the Beer's law within 0.5-2.5 μg·mL-1.The color reaction was highly stable and didnot show any change in absorbance up to 24 h.The method was applied for the analysis of TA from capsules,injections and tooth pastes.The amounts of TA found in capsules,injections and tooth pastes of various pharmaceutical companies were observed with 249.0-250.9 mg/capsule,249.3-250.7 mg/injection and 0.048%-0.049%in tooth pastes with relative standard deviation(RSD)0.2%-5.0%(n=3).
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Vanillin吸嗅对抑郁模型SD大鼠血清Mg2+的影响
目的 探讨嗅质香兰素(Vanillin)吸嗅对SD大鼠抑郁样行为的调节作用及可能的作用机制.方法 雄性SD大鼠70只,采用CUMS+孤养或嗅球毁损,制备抑郁样模型,符合模型大鼠随机分为Vanillin吸嗅组、氟西汀组、模型组、嗅球毁损+ Vanillin吸嗅组及假手术组.评价大鼠干预后各时间点的神经行为学变化及血清Mg2+含量.结果 (Vanillin吸嗅组干预2w后强迫游泳实验时间明显缩短(P ＜0.05);24h糖水消耗量实验明显增加(P＜0.05);5w后旷野实验自主活动次数增加(P＜0.05);血清Mg2含量明显提高(P＜0.05).结论 Vanillin吸嗅可以缓解抑郁模型大鼠的抑郁样行为,其机制可能是提高血清Mg2含量,通过Mg2调控HPA轴,影响海马、杏仁核情绪中枢活动,从而达到防治抑郁症的作用.
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姜酮的超声波法合成
姜酮(zingerone,1),化学名为4-(4-羟基-3-甲氧基苯基)丁酮,是抗炎药6-姜酚(gingerol)~([1])的重要中间体,也是一种新型香料,可用于食品、饮料及化妆品行业~[2].天然的1主要存在于生姜的提取物姜油中,但含量甚微,且不易提纯.工业合成大多以香兰素(2)为原料,与丙酮缩合制得脱氢姜酮(3),3再经Pd/C或Raney-Ni催化氢化得1~([1,3,4]),反应时间长(制备3需24 h,还原3需9 h),操作要求高.
