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磁共振T2*技术在测量人体内铁沉积中的研究进展
输血依赖型贫血患者体内可能存在大量异常铁沉积.过量铁沉积与患者的病死率以及并发症密切相关.准确测量靶器官铁含量将直接关系到临床诊断和治疗决策.本文主要从铁含量测量的必要性、目前存在的测量方法、磁共振T2*技术评估的原理和验证方法、铁沉积主要累及的靶器官等方面进行阐述和讨论.磁共振T2*技术作为目前一种无创评估人体内铁沉积的方法,已有一定的临床应用,但也存在伪影、测量方法欠优化等不足.随着不断的深入研究和改进,磁共振T2*技术在铁沉积患者中将有广泛的临床应用前景.
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铁过载在输血依赖性血液系统疾病的概述及进展
Iron is an indispensable element in human health. It has many functions in human body, such as synthesis and repair of DNA,participation in hemoglobin synthesis,redox reaction,cell proliferation and mitochondrial energy metabolism,and is an auxiliary factor of many enzymes. Iron overload or iron deficiency may cause corresponding symptoms,and sometimes even affect the progress of certain diseases. Iron deficiency will lead to iron deficiency anemia,which has been recognized by clinicians. Iron overload is divided into primary and secondary. Primary iron overload is mainly caused by congenital diseases. Secondary iron overload is mainly caused by long-term blood transfusion, ineffective hematopoiesis and excessive iron intake. Long term blood transfusion is the most common cause. The most common blood transfusion related diseases are myelodysplastic syndrome,aplastic anemia and acute hematopoietic malignancies. In foreign countries,there are many guidelines for the indications and practice of the treatment of iron overload caused by blood transfusion, but the occurrence and harmfulness have not been paid much attention interiorly. Thcrefore, this article focuses on the overview and progress of secondary iron overload in blood dependent blood system related diseases.
