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63 patients with senile vascular dementia were randomly divided into the treatment group (treated by acupuncture) and the control group (treated with piracetam). The authors observed the changes in the score of Hasegawa's dementia scale (HDS), p300, rheoencephalogram, topographic EEG, superoxide dismutase (SOD) activity in erythrocytes, and lipid peroxide (LPO) level in plasma before and after treatment. The statistical data showed that the total effective rate in the treatment group (80.6%) was significantly higher than that in the control group (25%), and the differences in the observed indexes before and after treatment were significant (P<0.05 or P<0.01) in the treatment group but not in the control group (P>0.05), indicating that the acupuncture treatment was superior in immediate therapeutic effect on senile vascular dementia to drug treatment.
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呆聪液对老年痴呆大鼠血清酶及LPO的影响
Objective To explore the effect of Daicong solution (DCS) on aged rats dementia model.Method The experiment used 22 month old rats whose basal nuclei was destroyed by bilateral electrolytic method as model for aged rats dementia.They were treated with DCS for a month.Then the level of superoxide dismutase (SOD),lipid peroxide(LPO),monoamine oxidase (MAO) and cholinesterase(CHE) in the serum was measured. Result Compared with the control,the activity of SOD increased markedly(P< 0.01), the content of LOP and activity MAO and CHE were decreased(P< 0.01).Conclusion DCS is effective in treating the aged dementia.
