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ABSTRACT:?CD98?has?been?described?to?play?a?crucial?role?in?tumor?progression?and?survival.?However,?the?role?of?CD98?in?biliary?tract?cancer?remains?unclear.?We?found?that?36.7%?of?all?patients?with?biliary?tract?cancer?had?a?high?CD98?expression.?Statistical?analysis?using?Spearman's?rank?correlation?showed?that?CD98?was?signiifcantly?correlated?with?L-type?amino?acid?transporter?1?(LAT1,?r=0.562,?P<0.001),?Ki-67?(r=0.230,?P=0.006)?and?CD34?(r=0.290,?P=0.005).?Multivariate?analysis?conifrmed?that?a?high?CD98?expression?was?an?independent?prognostic?factor?for?predicting?poor?outcome.?CD98?is?closely?associated?with?tumor?growth,?biological?aggressiveness,?and?survival?of?patients.?With?these?data?we?proposed?that?CD98?expression?is?necessary?for?the?development?and?pathogenesis?of?biliary?tract?cancer.
